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1.Cystic Fibrosis is also a recessively inherited autosomal trait. Given the following pedigree
what are the chances of a child in generation IV having cystic fibrosis?

2. Huntington’s is inherited through a dominant mutation in a gene on chromosome 4. This
mutation causes brain cells in certain areas of the brain to be destroyed. Jenny knows that the
defective (H) gene that causes Huntington’s disease is a dominant gene.
If a person has one defective (H) gene, that person will have Huntington’s disease. Jenny hopes that
she got two normal genes! Jenny’s father refuses to be tested to see if he has the dominant gene that
causes Huntington’s disease. She wonders if she should get the genetic test. She also wonders if her
brother (Jeremy) or other members of her family should consider getting tested to see if they have the
defective (H) gene.
So Jenny spoke with a genetic counselor. The genetic counselor asked questions about Jenny’s
family and recorded the information to create a pedigree chart. Jenny explains that none of her
mother’s relatives have Huntington’s disease. But, her grandmother (her father’s mother) and two of
her aunts (her father’s sisters) have Huntington’s disease but she also has an uncle and an aunt who
do not have the disease. Draw a pedigree chart that represents Jenny’s father’s family to help you
answer what is the probability that Jenny or her brother will have Huntington’s disease?

3. Match the probable/possible genotypes for each of the 15 individuals below, given that the trait
being followed is sex-linked color-blindness? Use C to indicate the non-color-blind version of the
gene and c to indicate the color-blind version of the gene.

Individual 1
Individual 2
Individual 3
Individual 4

Individual 5

B. C-

Individual 6

C. c-

Individual 8

E. cc

Individuals 9 and 10

Individual 7

Individual 11
Individual 12

F. CC/cc
G Cc/cc
H CC/Cc/cc
I. c-/Cc

Individual 13
Individual 14
Individual 15

4. In the pedigree below, if the female, II-3, is found to have O+ what are the possible
phenotype(s) for II-4?

5. Based on the pedigree in question 4 what are the possible genotypes for I-2?

6. Given the pedigree in question 4, what are the possible genotypes for the offspring in generation
Ai ++, Ai +-, ii++ and ii +Ai ++, AA ++ and ii ++
Ai-- and ii-both A and B are possible
Both A and C are possible
Both B and C are possible

7. the pedigree above, use the ratios of the offspring in generation II make a prediction about the
genotype for I-2. Make sure to explain how you made your prediction.

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