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This paper outlines these issues concerning two different studies carried on cancer patients aimed at determining several fac

This paper outlines these issues concerning two different studies carried on cancer patients aimed at determining several fac

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Introduction

In carrying out research, the importance of having a clear understanding as to the setting of the study, the adequacy of the sample and using the appropriate sampling method cannot be gainsaid. This paper outlines these issues concerning two different studies carried on cancer patients aimed at determining several factors pertaining to their lives.

McMillan, S. C., & Small, B. J. (2007). Using the COPE intervention for family caregivers to improve symptoms of hospice homecare patients. Oncology Nursing Forum, 34(2), 313-21.Describe the population for this study.

This research is carried out in a large nonprofit hospice involved in the provision of home care. The patients included in the study were supposed to be adults who had been diagnosed with cancer as well as identified family caregivers. The caregivers and patients included in the research were also supposed to have sixth grade education at the minimum and be in a position to read and comprehend English. They should also attain a score of at least seven in the Short Portable Mental Status Questionnaire (SPMSQ) as well as at least 40 in the Palliative Performance Scale (PPS). Since the study concentrated on management of pain, constipation and dyspnea, the patients included in the research had to be experiencing two of them.

How was the sample selected? What are the strengths and weaknesses of this sampling strategy?

A sample of 329 home care patients suffering from cancer and family caregivers were selected and randomly grouped into three categories. One control group comprised of 109 people received standard care, another group with the same number received standard care and friendly visits while the third group comprised of 111 people received standard care and COPE intervention. This method of sampling is known as cluster sampling in which case naturally occurring groups would be selected and be included in a sample. In this method, the population would be divided into groups or samples. In some cases, rather than collecting data from every group, a sub-sample would be used.

Advantages of cluster sampling

Economical- expenditure is one of the major concerns in any sampling method. However, since the research will be carried out on clusters, the expenditure is tremendously reduced due to the fewer listing efforts incorporated (William 2007).

Feasibility- cluster sampling method is also more feasible when carrying out research on large populations (William 2007). Given that the population in the large hospice is in excess of 300, carrying out comprehensive research may not be very feasible and therefore, clustering the samples would make it more feasible.

Increased variability- unlike other sampling methods, cluster sampling comes with increased variability.

Disadvantages of cluster sampling

Sampling errors- cluster sampling comes with more errors compared to other sampling methods. In this case, beginners are discouraged from using this method.

Biased samples- in case the clusters in the populations have biased opinions, it then follows that the whole population would be inferred as having similar results, which may not be the case.

Were the subjects in this study vulnerable? Were there any risks for them as the result of participation in the research study?

In carrying out any form of research, the vulnerability of the variables used in the samples is taken into consideration (William 2007). In essence, the patients and caregivers used in the research are quite vulnerable given the terminal nature of their diseases. However, their participation in the research did not put them in any risk more so having in mind that they were to be under the constant watch of qualified medical analysts who ensured that they got all the necessary standard care.

Are there any HIPAA concerns that are evident in this study?

Health Insurance Portability and Accountability Act (HIPAA) is a legislation that requires physicians and doctors to ensure that the security and privacy of the patients’ medical information and use standard formats to submit electronic transactions. From the research, one deduces that the data was recorded in tapes, 10% of which were reviewed every month to evaluate whether the interveners provided the interventions in line with the protocols and ensure that COPE interventions groups and friendly visits were not mixed in the protocols. This raises questions on the safety of the data more so having in mind that the information could be accessed by the interveners at any time.

What methods were put in place to ensure that the subjects were giving true informed consent?

While carrying out research, obtaining the informed consent of the respondents is imperative to come up with the right data. In this research, apart from meeting other criteria, the patients had to consent to participating in it. There was a minimum requirement as to the education level of the respondents not to mention their capability to read and comprehend English. Combined with the minimum score in the Short Portable Mental Status Questionnaire (SPMSQ) and the Palliative Performance Scale (PPS), the respondents met the requirements as to the mental aptitudes necessary for giving true and informed consent.

What was the setting for the study?

The research was carried out in a large (nonprofit) hospice which provided home care to most patients. The study was on patients who had been diagnosed with cancer and family caregivers. Both were supposed to consent and have a minimum o sixth grade education not to mention their capability to read and comprehend English. The main focus of the study was on management of pain, constipation and dyspnea. Only patients with two of the conditions were included in the study.

Was the sample adequate for the research design that was selected?

Given the importance of sample adequacy in research, it is always important that a representative sample be constituted. While there is quite a large number of patients suffering from these conditions in varied parts of the world, it would be important to acknowledge that the 329 patients included in the study were adequate for the research design. This is especially having in mind that the patients in the facility were 480, in which case, almost all of them were involved in the study.

The following questions pertain to: Rosedale, M., & Fu, M. R. (2010). Confronting the unexpected: Temporal, situational, and attributive dimensions of distressing symptom experience for breast cancer survivors. Oncology Nursing Forum, 37(1), 28-33.

Describe the population for this study.

This research was carried among a group of women aged between 33 and who had successfully gone through active treatment for breast cancer between one to 18 years before this study. In essence, they were assured of confidentiality and data protection. The interviews were held in the participants’ homes, libraries or private offices depending on the participants’ preferences. The participants outlined that they experienced distressing and unexpected symptoms after undergoing breast cancer treatment. These symptoms included loss of energy, pain, impaired movement of limbs altered sexual experience, lymph-edema and cognitive disturbances. Apart from the persistence of cancer symptoms even after undergoing treatments, many of the participants would not talk about the real experience since they thought that their doctors or confidants expected them to go back to their pre-cancer selves or could not handle their fears.

How was the sample selected? What are the strengths and weaknesses of this sampling strategy?

Participants in the research were derived from a cancer survivors’ network. The sample comprised of 13 English-speaking women between the ages of 33 and 74. These women had completed an active treatment regimen for breast cancer about one to eighteen years before the study. This method of sampling is known as purposive sampling method, which is one of the none-probability sampling methods (William 2007). This method targets a defined group of individuals.

The advantage of this method of sampling is that it can be used in situations where one would want to study a population that is very rare or difficult to come by and recruit for research. Given the fears exhibited by the participants in the research, you can be sure that getting the appropriate subjects to participate in the study would be a herculean task (William 2007). Most of them are living in denial and are not sure whether anyone they disclose the information to will understand their plight. Other sampling methods would fail to identify the appropriate subjects but a purposive sampling method would come in handy (William 2007).

However, purposive sampling method may introduce bias in that the people used in the study may not be a true representative of the population who may not be available to participate.

Were the subjects in this study vulnerable? Were there any risks for them as the result of participation in the research study?

Right from the beginning of the study, it was evident that the subjects picked for research purposes were vulnerable. This is demonstrated by the insinuation that many people do not open up to their doctors or confidants as to the real experiences they are undergoing. They live in constant fear that their doctors would abandon them after misconstruing some symptoms as indications of cancer. In addition, they felt that as much as their loved ones understood their plight, they still expected them to go back to their pre-cancer selves. They basically could not understand why the participants were still suffering from certain symptoms if the cancer was gone. Nevertheless, their participation in this study did not pose any risks to the participants.

Are there any HIPAA concerns that are evident in this study?

HIPAA or Health Insurance Portability and Accountability Act aims at regulating the ability of physicians to disclose information of their patients to researchers. This enhances the security and privacy of the patients’ medical information as well as the use of standard format to submit electronic transactions. In this particular research, the issue of HIPAA does not arise since the data is retrieved from the American Cancer Society ACS and not a health care facility. In any case, the respondents in the research participated in it voluntarily and therefore any data derived was as a result of their own disclosure.

What methods were put in place to ensure that the subjects were giving true informed consent?

It is always important that the subjects participating in the study be done with a true informed consent of the participants (William, 2007). While the study may not explicitly state the requirements for the participants, it is worth noting that the participants’ were at a relatively advanced age (33-74). In addition, they were participating in the study by their own accord and by their own volition.

What was the setting for the study?

The participants were derived from a cancer survivors’ network called Reach for Recovery which is sponsored by American Cancer Society ACS. However, the interviews could take place at any setting depending on the preferences of the participants. The study was aimed at determining and outlining the distressing and unexpected symptoms that women who have undergone cancer

treatment experience. The study was set on the premise of the symptoms that women who have undergone breast cancer treatment experience afterwards. It was all in an effort to determine the symptoms that women continue experiencing even after undergoing treatment and how they were dealing with them.

Was the sample adequate for the research design that was selected?

In carrying out a research, the adequacy of the study has a bearing on the results. In this case, choosing a representative sample is prerequisite for the success of the study (William, 2007). However, given the large number of women who have been treated for cancer, a sample of thirteen women would barely be adequate to cover their opinions. This however does not undermine the fact that all of them agree on the symptoms that they experience after undergoing treatment.

References

William G. Cochran, (2007). Sampling Techniques, 3Rd Edition, Wiley India Pvt. Ltd.

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THOMAS CULLEN

THOMAS CULLEN

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THOMAS CULLEN

Success

Success has been one of the most desired phenomena for many people. Every person strives to succeed in every aspect of his life. It is noteworthy that success does not imply that an individual does not have some setbacks in his life. Indeed, it would be difficult to define success without setbacks. Success may be defined as the prosperous or favorable termination of an attempt or endeavor, which may be characterized by the attainment of position, wealth, honors and other aspects. Thomas Cullen can be said to be a success in more than one aspect of his life.

Having in mind that he had little success in his early life, it is surprising that he was able to turn himself from a moderate performer to a success. His grades were always on the middle at best, but by the time he was in Wharton College he was among the 10% of the class. In essence, he was able to overturn his academic performance from poor performance to relative excellence.

In addition, it is noteworthy that Thomas Cullen has managed to have a grip at defining what he wanted to do with his life. He defined that he wanted marketing and sought to sharpen his experience in the field. His stint in the detergent business with Procter and Gamble for 20 months was marked with success. In addition, he chose a post that other people were trying to evade and turned it into one of the most influential departments in McKinsey. It is not surprising that he also became one of the most influential and powerful people in the company. It is noteworthy that his position has continued to change with every new challenge bringing new success.

In the personal front, Thomas Cullen has managed to balance his family life with work. He knows that he is weak as far as emotions are concerned, but takes it all in his stride, allowing his children to have the best of him. All in all, he has defined success in his own way and followed it up.

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Rose City Council 1

Rose City Council 1

August 14, 2022

Xu ChunyuRose City Council 1

Government Centre

Mr. Stanley Evans

65 Karaka St.

Hyde Square, Rose City 0202

Dear Mr. Evans,

Thank you for your letter alerting us of the environmental issue you identified and for your past efforts to ensure our beautiful city remains that way. I apologize you and other environmentalist warriors have been subjected to frustrating efforts and a series of events. As a council, we pride ourselves on being conscious of our environment, therefore what you identified as a problem will be dealt with.

Upon a review of your claims, I found several issues that led to the conditions you brought up. The most serious is obviously the recognition of a need to expand our roads to international standards while retaining the integrity of our environment. You can be assured that the issue is being taken with the seriousness it deserves and your concerns are shared in our board.

I am happy to inform you that the council came up with a plan to still expand the roads while leaving the precious rata trees, because it is possible to achieve both Raroa Avenue expansion and the preservation of the trees. On that regard, the Rose City Council thanks you sincerely for helping to not only conserve our environment, but also to improve our services.

I appreciate you taking your time to remind the council of the community’s commitment to environmental conservation, an issue we share and pride ourselves of being champions towards. We strive to provide excellent service to our constituents. Please let us know if you have additional questions, comments, or concerns regarding the issue.

Thank you so much for your time.

Sincerely,

Xu Chunyu,

Communications Advisor

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Towards the Police (2)

Towards the Police (2)

Attitudes of HBCU Students Towards the Police

Ashlynn Ureste

Florida Memorial University

Senior Project

2/20/2022

Introduction

The study aims to investigate the attitudes towards the police among Historically Black Colleges and Universities (HBCUs) Students. Specifically, this research will assess perceptions of law enforcement from the perspective of HBCU students utilizing a questionnaire and quantitative analysis. Additionally, this study will investigate how the media influences these attitudes and how these attitudes and perceptions influence the police interaction with HBCU students. It is conjectured that the HBCU student population has unique attitudes and perceptions towards the police, which are a function of various factors, including fear of victimization, Police misconduct and the media. These attitudes lead to straining the quality of interaction between the police and students.

This section reviews research that aimed to address HBCU students’ perceptions of police by anchoring them in proven ideas. This section begins by analyzing numerous hypotheses crucial to understanding some other researchers’ results. Because most of the attitudes are characterized by racial identities, the theory addressed is the social labeling theory and its key tenets of how labeling reinforces the behavior, strains, relationships, leading to the confirmation of the social labels ADDIN CSL_CITATION {“citationItems”:[{“id”:”ITEM-1″,”itemData”:{“ISBN”:”042949811X”,”author”:[{“dropping-particle”:””,”family”:”Short”,”given”:”James F”,”non-dropping-particle”:””,”parse-names”:false,”suffix”:””}],”id”:”ITEM-1″,”issued”:{“date-parts”:[[“2018″]]},”publisher”:”Routledge”,”title”:”Poverty, ethnicity, and violent crime”,”type”:”book”},”uris”:[“http://www.mendeley.com/documents/?uuid=5c7d8c54-a207-4715-9932-8df2aa06fe58”]},{“id”:”ITEM-2″,”itemData”:{“ISSN”:”2153-3687″,”author”:[{“dropping-particle”:””,”family”:”Rocque”,”given”:”Michael”,”non-dropping-particle”:””,”parse-names”:false,”suffix”:””}],”container-title”:”Race and justice”,”id”:”ITEM-2″,”issue”:”3″,”issued”:{“date-parts”:[[“2011″]]},”page”:”292-315″,”publisher”:”SAGE Publications Sage CA: Los Angeles, CA”,”title”:”Racial disparities in the criminal justice system and perceptions of legitimacy: A theoretical linkage”,”type”:”article-journal”,”volume”:”1″},”uris”:[“http://www.mendeley.com/documents/?uuid=b2724f60-61a7-414a-b0a1-3d95548ea14b”]}],”mendeley”:{“formattedCitation”:”(Rocque, 2011; Short, 2018)”,”plainTextFormattedCitation”:”(Rocque, 2011; Short, 2018)”,”previouslyFormattedCitation”:”(Rocque, 2011; Short, 2018)”},”properties”:{“noteIndex”:0},”schema”:”https://github.com/citation-style-language/schema/raw/master/csl-citation.json”}(Rocque, 2011; Short, 2018). Socially labeling is discussed from two perspectives. The first perspective pertains to the history of the HBCU institutions being designed to give African Americans equal opportunities to higher education and the role of HBCU institutions to the identity of the progress of African AmericansADDIN CSL_CITATION {“citationItems”:[{“id”:”ITEM-1″,”itemData”:{“ISSN”:”1537-7938″,”author”:[{“dropping-particle”:””,”family”:”Webb”,”given”:”Patrick”,”non-dropping-particle”:””,”parse-names”:false,”suffix”:””},{“dropping-particle”:””,”family”:”Frame”,”given”:”Kimberly”,”non-dropping-particle”:””,”parse-names”:false,”suffix”:””},{“dropping-particle”:””,”family”:”Marshall”,”given”:”Pam”,”non-dropping-particle”:””,”parse-names”:false,”suffix”:””}],”container-title”:”Journal of ethnicity in criminal justice”,”id”:”ITEM-1″,”issue”:”2″,”issued”:{“date-parts”:[[“2018″]]},”page”:”137-155″,”publisher”:”Taylor & Francis”,”title”:”Correlates of campus crime: An exploration of minority attitudes at an HBCU”,”type”:”article-journal”,”volume”:”16″},”uris”:[“http://www.mendeley.com/documents/?uuid=7d3cacc1-c500-4963-9f43-46307a72a8c7”]},{“id”:”ITEM-2″,”itemData”:{“ISSN”:”1082-8354″,”author”:[{“dropping-particle”:””,”family”:”Murty”,”given”:”Komanduri S”,”non-dropping-particle”:””,”parse-names”:false,”suffix”:””},{“dropping-particle”:””,”family”:”Roebuck”,”given”:”Julian B”,”non-dropping-particle”:””,”parse-names”:false,”suffix”:””}],”container-title”:”Race, Gender & Class”,”id”:”ITEM-2″,”issue”:”3-4″,”issued”:{“date-parts”:[[“2015″]]},”page”:”136-153″,”publisher”:”JSTOR”,”title”:”African American HBCU students’ attitudes and actions toward interracial dating & marriage: A survey analysis”,”type”:”article-journal”,”volume”:”22″},”uris”:[“http://www.mendeley.com/documents/?uuid=d717ecf4-5cc4-4c74-b996-4d5275e67092″]}],”mendeley”:{“formattedCitation”:”(Murty & Roebuck, 2015; Webb et al., 2018)”,”plainTextFormattedCitation”:”(Murty & Roebuck, 2015; Webb et al., 2018)”,”previouslyFormattedCitation”:”(Murty & Roebuck, 2015; Webb et al., 2018)”},”properties”:{“noteIndex”:0},”schema”:”https://github.com/citation-style-language/schema/raw/master/csl-citation.json”}(Murty & Roebuck, 2015; Webb et al., 2018). Regarding the criminal justice system, the African American population has been overrepresented, which has led to the criminal justice system labeling African Americans as more likely to commit crimes. However, various incidents highlighting the interaction between law enforcement have depicted law enforcement officers as racially biased against African AmericansADDIN CSL_CITATION {“citationItems”:[{“id”:”ITEM-1″,”itemData”:{“ISSN”:”1043-9862″,”author”:[{“dropping-particle”:””,”family”:”Cochran”,”given”:”Joshua C”,”non-dropping-particle”:””,”parse-names”:false,”suffix”:””},{“dropping-particle”:””,”family”:”Warren”,”given”:”Patricia Y”,”non-dropping-particle”:””,”parse-names”:false,”suffix”:””}],”container-title”:”Journal of contemporary criminal justice”,”id”:”ITEM-1″,”issue”:”2″,”issued”:{“date-parts”:[[“2012″]]},”page”:”206-227″,”publisher”:”Sage Publications Sage CA: Los Angeles, CA”,”title”:”Racial, ethnic, and gender differences in perceptions of the police: The salience of officer race within the context of racial profiling”,”type”:”article-journal”,”volume”:”28″},”uris”:[“http://www.mendeley.com/documents/?uuid=ebb97614-ed41-49c8-8669-8c750cd7210a”]},{“id”:”ITEM-2″,”itemData”:{“author”:[{“dropping-particle”:””,”family”:”Lewis”,”given”:”Lisa Marie”,”non-dropping-particle”:””,”parse-names”:false,”suffix”:””}],”id”:”ITEM-2″,”issued”:{“date-parts”:[[“2016″]]},”title”:”Attitudes Toward Police among College Students: Differences among Race, Social Work Status, and University History”,”type”:”article-journal”},”uris”:[“http://www.mendeley.com/documents/?uuid=68b816ab-8496-4e27-80b5-a51d9d52c4c1″]}],”mendeley”:{“formattedCitation”:”(Cochran & Warren, 2012; Lisa Marie Lewis, 2016)”,”plainTextFormattedCitation”:”(Cochran & Warren, 2012; Lisa Marie Lewis, 2016)”,”previouslyFormattedCitation”:”(Cochran & Warren, 2012; Lisa Marie Lewis, 2016)”},”properties”:{“noteIndex”:0},”schema”:”https://github.com/citation-style-language/schema/raw/master/csl-citation.json”}(Cochran & Warren, 2012; Lisa Marie Lewis, 2016). For example, black individuals may be arrested more often because they are more likely to be living in poverty, which may explain why they are more likely to be arrested. Therefore, the social labeling theory is discussed from law enforcement and the African American HBCU students’ perspectives.

It will next seek to examine and incorporate research that sought to determine the prevalent opinions of HBCU students towards the police. Because perceptions impact student-police encounters, a brief discussion of police viewpoints will be conducted (Lisa M Lewis et al., 2017; Posick et al., 2013). The origins of the prevalent views will also be addressed. This will help explore how attitudes have evolved and continue to change.

The media’s influence in shaping impressions is discussed next. The emphasis will be on how the media portrays Police-African American relations. They consider it as their obligation to reject injustices starting with racial discrimination since it is the most directly impacts the history and identity of HBCU institutions. The part will examine how media coverage of police violence leads to internalization of police prejudice against African Americans and bad opinions of policing (Davies et al., 2017). The literature review will end with how unfavorable police attitudes reinforce one other. When HBCU students regard law enforcement authorities as racist, they are less likely to comply. This will lead to confrontations between police and students during campus protests and rallies. These hostile exchanges might lead to violence, which reinforces unfavorable impressions. Because such incidents may be quickly posted on social media, it promotes bad impressions of police to other HBCUs.

Literature Review

Social Labelling Theory

Social labeling refers to how different groups of people attach different labels to different types of people based on whether they are perceived as acceptable or unacceptable ADDIN CSL_CITATION {“citationItems”:[{“id”:”ITEM-1″,”itemData”:{“ISBN”:”1315864258″,”author”:[{“dropping-particle”:””,”family”:”Lynch”,”given”:”Michael J”,”non-dropping-particle”:””,”parse-names”:false,”suffix”:””}],”container-title”:”Race, Gender, and Class in Criminology the Intersections”,”id”:”ITEM-1″,”issued”:{“date-parts”:[[“2019″]]},”page”:”3-28″,”publisher”:”Routledge”,”title”:”Class, Race, Gender and Criminology: Structured Choices and the Life Course.”,”type”:”chapter”},”uris”:[“http://www.mendeley.com/documents/?uuid=551438eb-f752-458e-acb2-557bbafa4d82″]}],”mendeley”:{“formattedCitation”:”(Lynch, 2019)”,”plainTextFormattedCitation”:”(Lynch, 2019)”,”previouslyFormattedCitation”:”(Lynch, 2019)”},”properties”:{“noteIndex”:0},”schema”:”https://github.com/citation-style-language/schema/raw/master/csl-citation.json”}(Lynch, 2019).

Social labeling theory can be applied to several different aspects of life. It is applied in the different types of research conducted, including intergroup relations, social cognition, and intercultural communication. One area of research that the social labeling theory applies to is a student’s perspective of law enforcementADDIN CSL_CITATION {“citationItems”:[{“id”:”ITEM-1″,”itemData”:{“ISSN”:”1572-8315″,”author”:[{“dropping-particle”:””,”family”:”Rosenbaum”,”given”:”Dennis P”,”non-dropping-particle”:””,”parse-names”:false,”suffix”:””},{“dropping-particle”:””,”family”:”Lawrence”,”given”:”Daniel S”,”non-dropping-particle”:””,”parse-names”:false,”suffix”:””},{“dropping-particle”:””,”family”:”Hartnett”,”given”:”Susan M”,”non-dropping-particle”:””,”parse-names”:false,”suffix”:””},{“dropping-particle”:””,”family”:”McDevitt”,”given”:”Jack”,”non-dropping-particle”:””,”parse-names”:false,”suffix”:””},{“dropping-particle”:””,”family”:”Posick”,”given”:”Chad”,”non-dropping-particle”:””,”parse-names”:false,”suffix”:””}],”container-title”:”Journal of Experimental Criminology”,”id”:”ITEM-1″,”issue”:”3″,”issued”:{“date-parts”:[[“2015″]]},”page”:”335-366″,”publisher”:”Springer”,”title”:”Measuring procedural justice and legitimacy at the local level: the police–community interaction survey”,”type”:”article-journal”,”volume”:”11″},”uris”:[“http://www.mendeley.com/documents/?uuid=3ed10a08-d43d-49e5-b025-543b6a2c71a7”]},{“id”:”ITEM-2″,”itemData”:{“ISSN”:”1043-9862″,”author”:[{“dropping-particle”:””,”family”:”Cochran”,”given”:”Joshua C”,”non-dropping-particle”:””,”parse-names”:false,”suffix”:””},{“dropping-particle”:””,”family”:”Warren”,”given”:”Patricia Y”,”non-dropping-particle”:””,”parse-names”:false,”suffix”:””}],”container-title”:”Journal of contemporary criminal justice”,”id”:”ITEM-2″,”issue”:”2″,”issued”:{“date-parts”:[[“2012″]]},”page”:”206-227″,”publisher”:”Sage Publications Sage CA: Los Angeles, CA”,”title”:”Racial, ethnic, and gender differences in perceptions of the police: The salience of officer race within the context of racial profiling”,”type”:”article-journal”,”volume”:”28″},”uris”:[“http://www.mendeley.com/documents/?uuid=ebb97614-ed41-49c8-8669-8c750cd7210a”]},{“id”:”ITEM-3″,”itemData”:{“author”:[{“dropping-particle”:””,”family”:”Lewis”,”given”:”Lisa Marie”,”non-dropping-particle”:””,”parse-names”:false,”suffix”:””}],”id”:”ITEM-3″,”issued”:{“date-parts”:[[“2016″]]},”title”:”Attitudes Toward Police among College Students: Differences among Race, Social Work Status, and University History”,”type”:”article-journal”},”uris”:[“http://www.mendeley.com/documents/?uuid=68b816ab-8496-4e27-80b5-a51d9d52c4c1″]}],”mendeley”:{“formattedCitation”:”(Cochran & Warren, 2012; Lisa Marie Lewis, 2016; Rosenbaum et al., 2015)”,”plainTextFormattedCitation”:”(Cochran & Warren, 2012; Lisa Marie Lewis, 2016; Rosenbaum et al., 2015)”,”previouslyFormattedCitation”:”(Cochran & Warren, 2012; Lisa Marie Lewis, 2016; Rosenbaum et al., 2015)”},”properties”:{“noteIndex”:0},”schema”:”https://github.com/citation-style-language/schema/raw/master/csl-citation.json”}(Cochran & Warren, 2012; Lisa Marie Lewis, 2016; Rosenbaum et al., 2015). This perspective begins with the idea that being African American will place some African Americans in a disadvantageous position when dealing with law enforcement officers. This disadvantage can come from discrimination by the police based on race discrimination or from interactions with police officers where students may feel uncomfortable due to negative beliefs within society. This is with regard to Unjustified labels that police put on people and subsequently spread to others in the same community who have not had direct contact with law enforcement are included in this category.

Social labeling theory has been applied to African American HBCU (Historically Black Colleges and Universities) students in their interactions with law enforcement and the police. The theory states that different racial groups develop differential identifications with different social labels, such as “criminal. African Americans are usually more likely to be socially labeled as criminals by law enforcement agencies than Whites ADDIN CSL_CITATION {“citationItems”:[{“id”:”ITEM-1″,”itemData”:{“ISBN”:”1392244838″,”author”:[{“dropping-particle”:””,”family”:”Harris-Wyatt”,”given”:”Georgetta A”,”non-dropping-particle”:””,”parse-names”:false,”suffix”:””}],”id”:”ITEM-1″,”issued”:{“date-parts”:[[“2019″]]},”publisher”:”Tennessee State University”,”title”:”An Analysis of Factors that Impact Civilian Attitudes Toward Police Treatment of Minority Males”,”type”:”article”},”uris”:[“http://www.mendeley.com/documents/?uuid=04037b4e-fef5-41a5-912f-53cb8c316a3a”]},{“id”:”ITEM-2″,”itemData”:{“ISSN”:”1572-8315″,”author”:[{“dropping-particle”:””,”family”:”Rosenbaum”,”given”:”Dennis P”,”non-dropping-particle”:””,”parse-names”:false,”suffix”:””},{“dropping-particle”:””,”family”:”Lawrence”,”given”:”Daniel S”,”non-dropping-particle”:””,”parse-names”:false,”suffix”:””},{“dropping-particle”:””,”family”:”Hartnett”,”given”:”Susan M”,”non-dropping-particle”:””,”parse-names”:false,”suffix”:””},{“dropping-particle”:””,”family”:”McDevitt”,”given”:”Jack”,”non-dropping-particle”:””,”parse-names”:false,”suffix”:””},{“dropping-particle”:””,”family”:”Posick”,”given”:”Chad”,”non-dropping-particle”:””,”parse-names”:false,”suffix”:””}],”container-title”:”Journal of Experimental Criminology”,”id”:”ITEM-2″,”issue”:”3″,”issued”:{“date-parts”:[[“2015″]]},”page”:”335-366″,”publisher”:”Springer”,”title”:”Measuring procedural justice and legitimacy at the local level: the police–community interaction survey”,”type”:”article-journal”,”volume”:”11″},”uris”:[“http://www.mendeley.com/documents/?uuid=3ed10a08-d43d-49e5-b025-543b6a2c71a7″]}],”mendeley”:{“formattedCitation”:”(Harris-Wyatt, 2019; Rosenbaum et al., 2015)”,”plainTextFormattedCitation”:”(Harris-Wyatt, 2019; Rosenbaum et al., 2015)”,”previouslyFormattedCitation”:”(Harris-Wyatt, 2019; Rosenbaum et al., 2015)”},”properties”:{“noteIndex”:0},”schema”:”https://github.com/citation-style-language/schema/raw/master/csl-citation.json”}(Harris-Wyatt, 2019; Rosenbaum et al., 2015). Blacks and Whites differ in their use of social labeling to create differential identifications with what is labeled as good or bad. Whites used social labeling more often to assign positive labels, whereas Blacks used it more frequently to assign negative labels. African American students use higher levels of social labeling than White students, and that these differences exist throughout the lifecycle of their academic experiences at college (Riddle & Sinclair, 2019). This can be attributed to where they are coming from and what they have been going through. As a result of their hardships, they view the whites to be more privileged than them.

Other studies show that blacks are more likely than whites to have positive attitudes toward law enforcement officers with dark-skinned faces (Bowman, 2020). This shows the effect of reciprocity and social identity. Whereas law enforcement officers sometimes victimize African Americans because of their skin color, they may have general negative perceptions about the law enforcement while having more favorable perceptions to African American law enforcement officersADDIN CSL_CITATION {“citationItems”:[{“id”:”ITEM-1″,”itemData”:{“ISSN”:”1082-8354″,”author”:[{“dropping-particle”:””,”family”:”Murty”,”given”:”Komanduri S”,”non-dropping-particle”:””,”parse-names”:false,”suffix”:””},{“dropping-particle”:””,”family”:”Roebuck”,”given”:”Julian B”,”non-dropping-particle”:””,”parse-names”:false,”suffix”:””}],”container-title”:”Race, Gender & Class”,”id”:”ITEM-1″,”issue”:”3-4″,”issued”:{“date-parts”:[[“2015″]]},”page”:”136-153″,”publisher”:”JSTOR”,”title”:”African American HBCU students’ attitudes and actions toward interracial dating & marriage: A survey analysis”,”type”:”article-journal”,”volume”:”22″},”uris”:[“http://www.mendeley.com/documents/?uuid=d717ecf4-5cc4-4c74-b996-4d5275e67092″]}],”mendeley”:{“formattedCitation”:”(Murty & Roebuck, 2015)”,”plainTextFormattedCitation”:”(Murty & Roebuck, 2015)”,”previouslyFormattedCitation”:”(Murty & Roebuck, 2015)”},”properties”:{“noteIndex”:0},”schema”:”https://github.com/citation-style-language/schema/raw/master/csl-citation.json”}(Murty & Roebuck, 2015). On the other hand, African American law enforcement officers are perceived as less likely to discriminate against black students than light-skinned officers. The positive perceptions among African American students about these officers may result from the fact that they are viewed as having a more personal relationship with the students.

Perceptions Between Police and HBCU students

In a country where the Black population is a mere 13 percent, over 50 percent of all police killings in 2019 have been committed against black people (Bialik, 2021). For a greater context, it should be understood that as of 2019, African Americans made up 54.9 percent of all murder perpetrators, whites made up 41.1 per cent, and “Other” made up 3.0 percent of instances where the race was known. 54.7 percent of murder victims in 2019 were black or African-American, 42.3% were white, and 3.1 percent were of other races (Expanded Homicide, 2019) This staggering statistic highlights how Black Americans, both on and off-campus, are subjected to arbitrary violence at rates disproportionate to their representation in society. Furthermore, according to a 2018 study from the Higher Education Research Institute at UCLA, HBCU students are more likely to feel unsafe on campus than other universitiesADDIN CSL_CITATION {“citationItems”:[{“id”:”ITEM-1″,”itemData”:{“ISSN”:”2153-3687″,”author”:[{“dropping-particle”:””,”family”:”Posick”,”given”:”Chad”,”non-dropping-particle”:””,”parse-names”:false,”suffix”:””},{“dropping-particle”:””,”family”:”Rocque”,”given”:”Michael”,”non-dropping-particle”:””,”parse-names”:false,”suffix”:””},{“dropping-particle”:””,”family”:”McDevitt”,”given”:”Jack”,”non-dropping-particle”:””,”parse-names”:false,”suffix”:””}],”container-title”:”Race and Justice”,”id”:”ITEM-1″,”issue”:”3″,”issued”:{“date-parts”:[[“2013″]]},”page”:”190-209″,”publisher”:”SAGE Publications Sage CA: Los Angeles, CA”,”title”:”One scale fits all? Assessing racial differences in the measurement of attitudes toward the police”,”type”:”article-journal”,”volume”:”3″},”uris”:[“http://www.mendeley.com/documents/?uuid=39c3cdd3-d84c-44a3-bf55-a794dbaad57a”]},{“id”:”ITEM-2″,”itemData”:{“ISSN”:”0888-6601″,”author”:[{“dropping-particle”:””,”family”:”Lewis”,”given”:”Lisa M”,”non-dropping-particle”:””,”parse-names”:false,”suffix”:””},{“dropping-particle”:””,”family”:”Wilks”,”given”:”Scott E”,”non-dropping-particle”:””,”parse-names”:false,”suffix”:””},{“dropping-particle”:””,”family”:”Geiger”,”given”:”Jennifer R”,”non-dropping-particle”:””,”parse-names”:false,”suffix”:””},{“dropping-particle”:””,”family”:”Barthelemy”,”given”:”Juan J”,”non-dropping-particle”:””,”parse-names”:false,”suffix”:””},{“dropping-particle”:””,”family”:”Livermore”,”given”:”Michelle M”,”non-dropping-particle”:””,”parse-names”:false,”suffix”:””}],”container-title”:”Journal of Pan African Studies”,”id”:”ITEM-2″,”issue”:”1″,”issued”:{“date-parts”:[[“2017″]]},”title”:”A Racial Divide: College Student Attitudes Concerning Police in South Louisiana.”,”type”:”article-journal”,”volume”:”10″},”uris”:[“http://www.mendeley.com/documents/?uuid=09d5aecb-4373-47fd-a014-452c3fe5fcd2”]},{“id”:”ITEM-3″,”itemData”:{“ISSN”:”0734-0168″,”author”:[{“dropping-particle”:””,”family”:”Gabbidon”,”given”:”Shaun L”,”non-dropping-particle”:””,”parse-names”:false,”suffix”:””},{“dropping-particle”:””,”family”:”Higgins”,”given”:”George E”,”non-dropping-particle”:””,”parse-names”:false,”suffix”:””},{“dropping-particle”:””,”family”:”Potter”,”given”:”Hillary”,”non-dropping-particle”:””,”parse-names”:false,”suffix”:””}],”container-title”:”Criminal justice review”,”id”:”ITEM-3″,”issue”:”1″,”issued”:{“date-parts”:[[“2011″]]},”page”:”5-21″,”publisher”:”SAGE Publications Sage CA: Los Angeles, CA”,”title”:”Race, gender, and the perception of recently experiencing unfair treatment by the police: Exploratory results from an all-black sample”,”type”:”article-journal”,”volume”:”36″},”uris”:[“http://www.mendeley.com/documents/?uuid=be923f59-a9e5-4d1a-8fcb-2dccda5efcc5″]}],”mendeley”:{“formattedCitation”:”(Gabbidon et al., 2011; Lisa M Lewis et al., 2017; Posick et al., 2013)”,”plainTextFormattedCitation”:”(Gabbidon et al., 2011; Lisa M Lewis et al., 2017; Posick et al., 2013)”,”previouslyFormattedCitation”:”(Gabbidon et al., 2011; Lisa M Lewis et al., 2017; Posick et al., 2013)”},”properties”:{“noteIndex”:0},”schema”:”https://github.com/citation-style-language/schema/raw/master/csl-citation.json”}(Gabbidon et al., 2011; Lisa M Lewis et al., 2017; Posick et al., 2013). This fear can be linked to several factors: incarceration rates among Black teenagers have increased by 44% since 1990, while white incarcerations have only increased by 3%. In addition, according to a report by the Bureau of Justice Statistics, Black students are more likely to be arrested on campus. Finally, the mere presence of police on campus can cause an environment of fear and self-preservation among studentsADDIN CSL_CITATION {“citationItems”:[{“id”:”ITEM-1″,”itemData”:{“ISSN”:”1537-7938″,”author”:[{“dropping-particle”:””,”family”:”Webb”,”given”:”Patrick”,”non-dropping-particle”:””,”parse-names”:false,”suffix”:””},{“dropping-particle”:””,”family”:”Frame”,”given”:”Kimberly”,”non-dropping-particle”:””,”parse-names”:false,”suffix”:””},{“dropping-particle”:””,”family”:”Marshall”,”given”:”Pam”,”non-dropping-particle”:””,”parse-names”:false,”suffix”:””}],”container-title”:”Journal of ethnicity in criminal justice”,”id”:”ITEM-1″,”issue”:”2″,”issued”:{“date-parts”:[[“2018″]]},”page”:”137-155″,”publisher”:”Taylor & Francis”,”title”:”Correlates of campus crime: An exploration of minority attitudes at an HBCU”,”type”:”article-journal”,”volume”:”16″},”uris”:[“http://www.mendeley.com/documents/?uuid=7d3cacc1-c500-4963-9f43-46307a72a8c7″]}],”mendeley”:{“formattedCitation”:”(Webb et al., 2018)”,”plainTextFormattedCitation”:”(Webb et al., 2018)”,”previouslyFormattedCitation”:”(Webb et al., 2018)”},”properties”:{“noteIndex”:0},”schema”:”https://github.com/citation-style-language/schema/raw/master/csl-citation.json”}(Webb et al., 2018). If a student feels threatened by a police officer’s presence, there is no doubt that they will alter their behavior in some way for fear of being harmed or unjustifiably arrested.

According to the National Center for Education Statistics, 102 Historically Black Colleges and Universities (HBCUs) in the United States. Many of these schools were founded during segregation to offer education opportunities to African Americans who had been previously denied access to higher learning institutions. These colleges still retain many of their original values, including strong support for diversity and multiculturalism. HBCUs experience a very different college life than non-HBCU’s, which is heavily affected by their race/ethnicityADDIN CSL_CITATION {“citationItems”:[{“id”:”ITEM-1″,”itemData”:{“ISBN”:”1392244838″,”author”:[{“dropping-particle”:””,”family”:”Harris-Wyatt”,”given”:”Georgetta A”,”non-dropping-particle”:””,”parse-names”:false,”suffix”:””}],”id”:”ITEM-1″,”issued”:{“date-parts”:[[“2019″]]},”publisher”:”Tennessee State University”,”title”:”An Analysis of Factors that Impact Civilian Attitudes Toward Police Treatment of Minority Males”,”type”:”article”},”uris”:[“http://www.mendeley.com/documents/?uuid=04037b4e-fef5-41a5-912f-53cb8c316a3a”]},{“id”:”ITEM-2″,”itemData”:{“ISSN”:”0888-6601″,”author”:[{“dropping-particle”:””,”family”:”Lewis”,”given”:”Lisa M”,”non-dropping-particle”:””,”parse-names”:false,”suffix”:””},{“dropping-particle”:””,”family”:”Wilks”,”given”:”Scott E”,”non-dropping-particle”:””,”parse-names”:false,”suffix”:””},{“dropping-particle”:””,”family”:”Geiger”,”given”:”Jennifer R”,”non-dropping-particle”:””,”parse-names”:false,”suffix”:””},{“dropping-particle”:””,”family”:”Barthelemy”,”given”:”Juan J”,”non-dropping-particle”:””,”parse-names”:false,”suffix”:””},{“dropping-particle”:””,”family”:”Livermore”,”given”:”Michelle M”,”non-dropping-particle”:””,”parse-names”:false,”suffix”:””}],”container-title”:”Journal of Pan African Studies”,”id”:”ITEM-2″,”issue”:”1″,”issued”:{“date-parts”:[[“2017″]]},”title”:”A Racial Divide: College Student Attitudes Concerning Police in South Louisiana.”,”type”:”article-journal”,”volume”:”10″},”uris”:[“http://www.mendeley.com/documents/?uuid=09d5aecb-4373-47fd-a014-452c3fe5fcd2”]},{“id”:”ITEM-3″,”itemData”:{“ISSN”:”0734-0168″,”author”:[{“dropping-particle”:””,”family”:”Gabbidon”,”given”:”Shaun L”,”non-dropping-particle”:””,”parse-names”:false,”suffix”:””},{“dropping-particle”:””,”family”:”Higgins”,”given”:”George E”,”non-dropping-particle”:””,”parse-names”:false,”suffix”:””},{“dropping-particle”:””,”family”:”Potter”,”given”:”Hillary”,”non-dropping-particle”:””,”parse-names”:false,”suffix”:””}],”container-title”:”Criminal justice review”,”id”:”ITEM-3″,”issue”:”1″,”issued”:{“date-parts”:[[“2011″]]},”page”:”5-21″,”publisher”:”SAGE Publications Sage CA: Los Angeles, CA”,”title”:”Race, gender, and the perception of recently experiencing unfair treatment by the police: Exploratory results from an all-black sample”,”type”:”article-journal”,”volume”:”36″},”uris”:[“http://www.mendeley.com/documents/?uuid=be923f59-a9e5-4d1a-8fcb-2dccda5efcc5″]}],”mendeley”:{“formattedCitation”:”(Gabbidon et al., 2011; Harris-Wyatt, 2019; Lisa M Lewis et al., 2017)”,”plainTextFormattedCitation”:”(Gabbidon et al., 2011; Harris-Wyatt, 2019; Lisa M Lewis et al., 2017)”,”previouslyFormattedCitation”:”(Gabbidon et al., 2011; Harris-Wyatt, 2019; Lisa M Lewis et al., 2017)”},”properties”:{“noteIndex”:0},”schema”:”https://github.com/citation-style-language/schema/raw/master/csl-citation.json”}(Gabbidon et al., 2011; Harris-Wyatt, 2019; Lisa M Lewis et al., 2017). A large body of research supports this notion. Due to the heavy racial segregation that HBCUs experienced, they are likely to attract students more concerned with race relations.

Another aspect of research surrounding the HBCU student body is that of crime and perceptions of criminality. According to a 2016’s study by Columbia University’s National Opinion Research Center (NORC), even though there is little evidence suggesting racial bias in college campus crime, Black students perceived police treatment as biased against themADDIN CSL_CITATION {“citationItems”:[{“id”:”ITEM-1″,”itemData”:{“ISSN”:”2153-3687″,”author”:[{“dropping-particle”:””,”family”:”Posick”,”given”:”Chad”,”non-dropping-particle”:””,”parse-names”:false,”suffix”:””},{“dropping-particle”:””,”family”:”Rocque”,”given”:”Michael”,”non-dropping-particle”:””,”parse-names”:false,”suffix”:””},{“dropping-particle”:””,”family”:”McDevitt”,”given”:”Jack”,”non-dropping-particle”:””,”parse-names”:false,”suffix”:””}],”container-title”:”Race and Justice”,”id”:”ITEM-1″,”issue”:”3″,”issued”:{“date-parts”:[[“2013″]]},”page”:”190-209″,”publisher”:”SAGE Publications Sage CA: Los Angeles, CA”,”title”:”One scale fits all? Assessing racial differences in the measurement of attitudes toward the police”,”type”:”article-journal”,”volume”:”3″},”uris”:[“http://www.mendeley.com/documents/?uuid=39c3cdd3-d84c-44a3-bf55-a794dbaad57a”]},{“id”:”ITEM-2″,”itemData”:{“ISSN”:”1082-8354″,”author”:[{“dropping-particle”:””,”family”:”Murty”,”given”:”Komanduri S”,”non-dropping-particle”:””,”parse-names”:false,”suffix”:””},{“dropping-particle”:””,”family”:”Roebuck”,”given”:”Julian B”,”non-dropping-particle”:””,”parse-names”:false,”suffix”:””}],”container-title”:”Race, Gender & Class”,”id”:”ITEM-2″,”issue”:”3-4″,”issued”:{“date-parts”:[[“2015″]]},”page”:”136-153″,”publisher”:”JSTOR”,”title”:”African American HBCU students’ attitudes and actions toward interracial dating & marriage: A survey analysis”,”type”:”article-journal”,”volume”:”22″},”uris”:[“http://www.mendeley.com/documents/?uuid=d717ecf4-5cc4-4c74-b996-4d5275e67092″]}],”mendeley”:{“formattedCitation”:”(Murty & Roebuck, 2015; Posick et al., 2013)”,”plainTextFormattedCitation”:”(Murty & Roebuck, 2015; Posick et al., 2013)”,”previouslyFormattedCitation”:”(Murty & Roebuck, 2015; Posick et al., 2013)”},”properties”:{“noteIndex”:0},”schema”:”https://github.com/citation-style-language/schema/raw/master/csl-citation.json”}(Murty & Roebuck, 2015; Posick et al., 2013). In addition, that same study reported that Blacks and Whites differ in their perceptions towards criminal behavior: Black people were more likely than white people to think the majority of crime victims were black and less likely than whites to think most members of society viewed blacks favorably.

The Role of Media in Influencing HBCU students’ perceptions of police

The past decade has seen numerous protests and demonstrations by HBCU students on issues of racial discrimination. These protests and demonstrations have a constitutional grounding based on freedoms of speech, assembly, and government petitioning. However, some of these pretests are accompanied by violence which necessitates the involvement of law enforcement. In most cases, the involvement of the police only serves to heighten tensions since the law enforcement institutions have negative connotations of being biased against African AmericansADDIN CSL_CITATION {“citationItems”:[{“id”:”ITEM-1″,”itemData”:{“ISSN”:”1537-7938″,”author”:[{“dropping-particle”:””,”family”:”Webb”,”given”:”Patrick”,”non-dropping-particle”:””,”parse-names”:false,”suffix”:””},{“dropping-particle”:””,”family”:”Frame”,”given”:”Kimberly”,”non-dropping-particle”:””,”parse-names”:false,”suffix”:””},{“dropping-particle”:””,”family”:”Marshall”,”given”:”Pam”,”non-dropping-particle”:””,”parse-names”:false,”suffix”:””}],”container-title”:”Journal of ethnicity in criminal justice”,”id”:”ITEM-1″,”issue”:”2″,”issued”:{“date-parts”:[[“2018″]]},”page”:”137-155″,”publisher”:”Taylor & Francis”,”title”:”Correlates of campus crime: An exploration of minority attitudes at an HBCU”,”type”:”article-journal”,”volume”:”16″},”uris”:[“http://www.mendeley.com/documents/?uuid=7d3cacc1-c500-4963-9f43-46307a72a8c7”]},{“id”:”ITEM-2″,”itemData”:{“ISBN”:”9798662447943″,”author”:[{“dropping-particle”:””,”family”:”Robinson”,”given”:”Corey D”,”non-dropping-particle”:””,”parse-names”:false,”suffix”:””}],”id”:”ITEM-2″,”issued”:{“date-parts”:[[“2020”]]},”publi

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Literature Review of industry life cycle

Literature Review of industry life cycle

At Literature Review of industry life cycle

The concept of industry life cycle is one that relates to the various stages that an industry moves through right from initial product entry, up to its eventual decline. Typically, there are five stages or phases in the industry lifecycle. Gort and Klepper (1982) originally identified these five stages. These five stages include early stage, innovation phase, shakeout or cost phase, maturity phase and finally decline phase. The work of Klepper (1997) explored the concept of industry life cycles. His work reviewed a series of evidence on the entry, exit, corporate survival, and product innovation and organization structure in new and emerging industries in order to assess if these industries go through the regular business cycles as they progress towards old age. His work acted as a clear depiction of what happens in the evolution of modern age industries and product life cycle is what is used in elucidating this evidence. Yoo (2000) explored the theory of Industry Life Cycle by deriving an equilibrium timing of both entries and exits, coupled with the equilibrium output levels spanning the entire industry life cycle period. His work also examined the effects of rise in entry costs. By means of an extended model having three entrants, his work indicated that the very fist entry might effectively be delayed with the third firm and that the less efficient company may be used as the first entrant in certain exceptional cases. Maksimovic and Phillips (2008) examined industry life cycle about acquisition and investment. Their main work was however aimed at finding out if really, the firm organization matters in this process.

The work of Volpato and Stocchetti (2008) explored the management of product life cycle in the auto manufacture industry. They did this by evaluating the effectiveness of the carmakers using the product life-cycle model. Their work discovered certain interesting results about product life cycle. The first one is that new product development process must be timed appropriately by planning with regard to several generation of a product that are to be developed on a similar platform as opposed to basing it on the next generation model only. Transition management from the marketing point of view must be conducted in order to ensure a successful sale of products. Product policy in the product life cycle process such as differentiation is not as effective as product innovation. Simons (2011) explored the characteristics of product markets and industry life cycle. The work of Giachetti, Marchi, and Corradini (2012) presented the best work on the concept of industry life cycle within the technology-based arena. Their work explored the evolution of company’s product strategy over the entire life cycle of information technology industries. The most interesting point that can be extracted from their work is that the global mobile phone industry experienced or entered the shake-out/cost phase in the 2000s. Strategy has therefore shifted from product towards process innovation. Innovation is also noted to play a major role in industry maturity.

1.1 Phases of industry life cycle

The work of Dinlersoz and MacDonald (2009) identified the following five phases in the development and maturity of an industry.

Early Stage Phase- This is an alternative product design as well as positioning stage. It involves the establishment of range as well as boundaries within a given industry

Innovation Phase- In this stage, product innovation is noted to decline while process innovation kicks in. It is at this phase that the ‘dominant design’ arrives

Shakeout Phase- At this stage, firms settle on their ‘dominant design’ and they achieve their economies of scale. This forces the smaller industry players to exit or be acquired. Barriers of entry get extremely high and large-scale consolidation is achieved.

Maturity- In this stage, growth is noted to be no longer the focus and both cash flow and market share become the main goal of firms that are left in operation.

Decline – At this stage, industries experience a decline in revenues. A new industry may replace the existing industry as a whole

This literature review indicates that there is a general lack of literature or knowledge on the role of industry life cycle in the development and marketing of information technology-based products and services such as the Android Smartphone technology system. In this paper, we explore this gap in knowledge through a critical analysis of the Smartphone industry. A case in point is how and when the Android OS changed the smartphone life cycle as depicted in Ferreira’s (2011) article.

2.0 Three themes that are present in Ferreira’s (2011) article titled “Android OS changes Smartphone life cycle”

A review of Ferreira’s (2011) work indicates that there are three main dominant themes. These are changing nature of customer needs, technological advancement and corporate social responsibility

2.1 Changing customer need

The global smartphone ecosystem is rapidly changing because of the dynamic nature of consumer needs. For companies to remain competitive, they must be able to identify with the rapidly changing consumer needs and then prioritize their aims and objectives along these lines. The smartphone industry has seen a phenomenal growth in terms of user experience and operating system development. The Android operating system, a derivation of Linux operating system has rapidly shifted consumer demands from the iOS powered iPhone to Android operating system devices.

Consumers’ need for stylish and highly multi-functional cell phones is what has driven the development of smartphones and their respective operating systems (Lin and Ye, 2008, p.617). It is important for manufacturers and other players within the smartphone ecosystem to monitor the dynamism of consumer needs in order help them in gaining a competitive advantage. Advancements within the smartphone ecosystem are continuously increasing and surpassing one another as new versions are constantly hitting the market at great speeds. According to Kano’s theory of customer satisfaction, customer satisfaction is directly proportional to the degree to which a given product or service is adequately functional. The changing nature of customer needs has led to constant operating system upgrades.

2.2 Technological advancement

Advances in technology have created a number of innovations within the smartphone ecosystem. The advent of Android operating system has resulted in the creation of better and more efficient smartphone systems. The Android technology offers a perfect example of how technology can be can be leveraged to enhance user experience CITATION HoT11 l 1033 (Ho & Chen, 2011)

2.3 Corporate Social Responsibility

Kotler and Lee (2005) defined the concept of corporate social responsibility as “a commitment to improve community well-being through discretionary business practices and contributions of corporate resources” (p.3). This means that a given business entity must have objectives that surpass financial gains. Within the smartphone ecosystem, players must ensure that all hardware and software applications are built while having the benefits to the community and environment in mind. In the past, the global smartphone industry was heavily criticized for building their hardware from minerals sourced through illegitimate and conflict-ridden sources. Titanium, Gold, Tungsten and Tin, the base materials for smartphones’ electronics were for long sourced from the eastern Democratic Republic. These minerals were being sourced in places where countless number lives were lost due to blood money generated from the illegal mining and smuggling activities in those areas. In other words, the money from minerals bought by the manufacturers of smartphones was being used to fund armed militias. This calls for some sort of accountability and social responsibility. In is also important for the smartphone application developers to ensure that their products consume less electricity or energy. This was they would be advancing the global sustainability agenda.

Industry background of smartphone industry life cycle  diagram and it’s industry analysis (use graphs) 

A review of extant literature suggests that the smartphone industry is approaching its maturity phase. The global smartphone industry is currently at an advanced growth phase. It is actually towards the end of growth phase and is fact-approaching maturity. Innovation is noted to be the key driver of this industry towards maturity CITATION Wes07 l 1033 (West & Mace, 2007).

Fig.1 Smartphone industry life cycle

Industry analysis

Introduction phase

The smartphone industry came into being in 1993 with the introduction of IBM Simon. This phone had PDA capabilities and was, arguably, the very first smartphone CITATION Ree10 l 1033 (Reed, 2010). This phase ended sometime in 1999.

Growth phase

The Smartphone industry entered its growth phase in 2002 with the multiple releases of smartphones such as Palm One, Pocket PC and Black Berry. This stage has had a steady rise but was recently forecasted to headed for a slump in growth rates (Kuittinen, 2013)

3.1 Apple industry life cycle and its analysis 

A review of Apple Inc operations reveals that its industry life cycle is a unique one. This is due to the nature of product life cycles that it maintains for virtually all of its products. According to Yadegari (2012), apple has a way of ensuring that its products are always in the introduction and growth phases. In this company, the introduction stage includes the release of the original iPad, iPhone as well as iPod. When it comes to the growth stage, the company has a way of maintaining its products in this stage and to them “backwards”

Fig.2 Apple’s industry life cycle

Within the product life cycle, instead of allowing its products to reach maturity phase, it releases new and improved features. The company does this by improving its product quality, styles and well as improving its technology. This is best seen in the way it handles its products such as iPad Mini and iMac product ranges.

Fig. 3 iPhone product life cycle (Euromonitor, 2011)

Apple’s makes minor upgrades to its hardware as well as features with every version. A perfect example is the use of product extension in its product ranges. This is aimed at taking care of the needs of various consumer segments. At a time when iPhone was approaching its maturity stage, it released a low-cost model of its iPhone 4 that has no front-facing camera as well as retina display. Euromonitor (2011) reiterated this to have been an excellent offer to the late notes this adopted in the emerging economies such as India and China.

3.2 Samsung industry life cycle and its analysis 

Samsung is an undisputed leader in the realm product life cycle design. The continuing rise in demand for smartphones coupled with competition that gets worse everyday makes indicates that the smartphone industry is at growth phase. This means that Samsung Mobile is at its growth phase as a company. The product life cycle of Samsung products is less than a year.

Critique of existing industry life cycle models and a review if they are valuable in today’s industry and what is it that it is missing. 

The concept of industry life cycle is, in a profound one. This is because companies can use it in setting out their short and long-term objectives. A company that knows that it operates in an industry at an advanced or mature stage must consider venturing into other industries with growth potential while those that operate within a growing industry must formulate strategies for gaining a competitive advantage and accumulating as must profit as possible.

Despite its noble potential, the concept of industry life cycle as conceptual frameworks fails to consider the importance of services to every industry. The work of Cusano, Suarez and Kahl (2007) noted that existing models of industry life cycle main focuses on the changes in both products and services but with a conspicuous failure to explore the role of services in the cycle. There is therefore a need for the role of services at various stages in industry evolution to be incorporated into the existing industry life cycle models.

References

BIBLIOGRAPHY Cussamano, M., Suarez, F. S., & Steve, K. (2007). Product,Process,Service:A New Industry Lifecycle Model. Massachussets: Massachussets Institute of Technology.

Dinlersoz, E., & MacDonald, G. (2009). The industry life cycle of the size distribution of firms. Review of Economic Dynamics , 648–667.

Eurominitor. (2011, August 2). Smartphones Strategy: Case Studies . Retrieved 5 24, 2013, from Euromonitor: http://blog.euromonitor.com/2011/08/smartphones-strategy-case-studies.html

Ferreira, A. (2011). Android OS changes smartphone life cycle.

Giachetti, C., Marchi, G., & Corradini, R. (2012). Users’ Ability to Anticipate Incremental and Radical Innovation in Online Communities: The Role of Product Knowledge and Willingness to Participate in the Community Life. Working Paper No. 15/2012. Department of Management, Università Ca’ Foscari Venezia.

Gort, M., & Klepper, S. (1982). Time Paths in the Diffusion of Product Innovations. 630-53.

Ho, T., & Chen, R. (2011). Leveraging NFC and LBS Technologies to Improve User Experiences. International Joint Conference on Service Science (pp. 17-21). Taipei, Taiwan: IEEE.

Klepper, S. (1997). Industry Life Cycles. Vol 6 (1) (pp. 145-81). Oxford University Press.

Kotler, P., & Lee, N. (2005). Corporate Social esponsibility: Doing the Most Good for Your Company and Your Cause. Hoboken, NJ: Wiley & Sons, Inc.

Kuittinen, T. (2013, April 4). How Dangerous is the Current Smartphone Slowdown? Retrieved May 24, 2013, from Forbers.com: http://www.forbes.com/sites/terokuittinen/2013/03/04/how-dangerous-is-the-current-smartphone-slowdown/

Lin, F., & Ye, W. (2009). Operating System Battle in the Ecosystem of Smartphone Industry. 2009 International Symposium on Information Engineering and Electronic Commerce (pp. 617-621). IEEE.

Maksimovic, V., & Phillips, G. (2008). The Industry Life Cycle, Acquisitions and Investment: Does Firm Organization Matter? Journal of Finance , 673-709.

Reed, B. (2010, June 18). A Brief History of Smartphones. Retrieved May 25, 2013, from PCWorld.com: http://www.pcworld.com/article/199243/a_brief_history_of_smartphones.html

Simons, K. L. (2011). Product Market Characteristics and the Industry Life Cycle. New York: Economics Department, Rensselae.

Volpato, G., & Stocchetti, A. (2008). Managing product life-cycle in the auto industry: evaluating carmakers effectiveness. MPRA Paper 29381. Germany: University Library of Munich.

West, J., & Mace, M. ( 2007). ENTERING A MATURE INDUSTRY THROUGH INNOVATION: APPLE S IPHONE. Paper presented at the DRUID Summer Conference 2007,, June 18 – 2. Copenhagen, CBS, Denmark.

Yadegari, S. (2012, October 24). Apple Inc. and the product life cycle. Retrieved May 25, 2013, from WordPress: http://symkt.wordpress.com/2012/10/24/apple-inc-and-the-product-life-cycle/

Yoo, J. (2000). A Theory of Industry Life Cycle. JOURNAL OF ECONOMIC DEVELOPMENT,Vol 25 (1) .

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Upon locating two articles from the CSU Online Library that discuss structuralism and functionalism

Upon locating two articles from the CSU Online Library that discuss structuralism and functionalism

Assignments

Student’s Name

Institutional Affiliation

Course Tittle

Professor’s Name

Date

Assignment Three

Upon locating two articles from the CSU Online Library that discuss structuralism and functionalism, I realized major similarities and differences between what we learned from the textbook and the information I found in the chosen articles. From the functionalism article, its origin usually is traced to a paper on the reflex arc by John Dewey of Chicago. Just like the textbook, he reasoned against the analytic approach of lessening reflex to its components and claimed instead that reflex required to be perceived in its more comprehensive framework as a synchronized system that functioned to acclimate the organism to its setting. The article asserts that Dewey was recognized mainly for his broadminded outlooks on education, having faith that learners ought to be active students and his philosophical works of literature on democracy. The article’s main difference is that functionality states that every aspect of society serves a function and is essential for society’s survival. According to both the textbook and the article, structuralism is broadly considered the first school of thought in psychology. This point of view centers on breaking down psychological processes into essential elements. The article demonstrates that major philosophers associated with structuralism include Edward Titchener and Wilhelm Wundt.

From the information I choose in the article and what I learned in class, structuralism was the initial school of psychology centered on breaking down mental processes into the most elementary elements. Functionalism was established as a reaction to structuralism and was influenced by the evolutionary philosophy of Charles Darwin and the work of William James (Benjamin, 2018). Functionalists pursued to elucidate the psychological processes more accurately and systematically. The article of functionality gives the same elucidation of functionality whereby it asserts that it is the doctrine that what makes something a thought, pain, desire relies not on its internal makeup, but exclusively on its functions, or the part it plays, in the mental structure of which it is a part. Specifically, functionalist philosophies take the individuality of a psychological state in determining its causal relationships to behavior, sensory stimulations, and other mental states.

The finding of an analysis from a functional perspective makes the concept clear for me. According to the article, the initial clear assertion of the functionalist theory originated from the 1906 APA executive discourse of James Angell, who clearly compared functionalism and structuralism, pointing out that structuralists were more likely to inquire about the question “What is consciousness?” while functionalists were more focused with the query “What is consciousness for?” This made them research subjects ranging from growing to abnormal psychology and making them concerned about single differences and how everyday problems can be solved using psychology.

Reading about Titchener’s background convinces me that structuralism is a more solid methodology. Edward Titchener was Wilhelm Wundt’s student who first came up with the term ‘structuralism’ and popularized the school of thought. Titchener, whose notions were not the same as those of his educator, felt that psychology ought to center on learning both the mind and the consciousness (Li, 2020). Titchener regarded consciousness as the amalgamation of all of our psychological experiences at any particular point in time. The mind, at that time, was the buildup of all of our involvements all through our lives. Titchener and his associated structuralists supposed that we could realize how psychological processes are organized and learn about higher thinking by dividing the mind into its basic parts (Huffman et al., 2017). The textbook and the article on structuralism and functionalism have similarities in a way that according to Titchener, the cognizant minds made up of three structure or modules: images, which are mental pictures of ideas, feelings, which are produced by sensory information, and affections, or the components that make up emotions.

Assignment 4

Behaviorism denotes a theory of learning that asserts that all behaviors are learned through interaction with the environment by a process known as conditioning. As a result, the behavior is just a response to environmental stimuli. I have used the principles of behaviorism on several occasions. The principles of behaviorism learning comprise of the role of consequences, schedules of reinforcement, the immediacy of consequences, the role of antecedents, reinforcers, punishers, and maintenance. I have ever tried the principles of behaviorism on my younger sister, who studies in a high school. My sister had a tendency of behaving poorly each time. I had to develop a behavior management system in hopes of motivating her to behave better. At the end of each day, if she conducted herself well at an acceptable level, I buy her chocolate. At the end of the week, if she behaved extremely well, I promise her a nice shoe. Once she behaves well for an additional one week, she then gets a new shoe. My hope was that a new shoe’s incentive would motivate her to behave extremely well and work hard in class. The hope is that she will continue to exhibit the desired behavior because of the shoe reward until it eventually turns into a habit.

Reference

Benjamin Jr, L. T. (2018). A brief history of modern psychology. John Wiley & Sons.

Huffman, K., Dowdell, K., & Sanderson, C. A. (2017). Psychology in action. John Wiley & Sons.

Li, R. (2020). Young Dewey and Zeitgeist in Psychology. In Rediscovering John Dewey (pp. 49-73). Palgrave Macmillan, Singapore.

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True because the yield to maturity for bond B is always pre-determined

True because the yield to maturity for bond B is always pre-determined

Bonds

Name

Course

Course instructor

Date

Question 1

True because the yield to maturity for bond B is always pre-determined and are therefore priced at a premium with lower yield to maturity by pricing them to the call thus depreciating the value of premium.

Question 2

Bond with greater interest risk is a 30 year BB rated bond from Canadian Duck Calls Incorporated because it is highly affected by risks such as inflation unlike a 30 year Canadian Government bond which is very certain and is not much affected because it is governments.

Question 3

Seniority of bonds is accompanied with lower coupon rates due to their less default risk because a company is likely to recover the assets on the most senior bonds compared to the junior bonds which have higher risk and pay rate.

Puttable bonds pay lower interest compared to other bonds without put option because an investor can recover all the investments in case the interest rates rise.

A Canada plus call feature has lower interest rate because an investor may refinance the bond in case the rates go high.

Bonds with deferred call provision normally experience lower interest rates which act as the tradeoff for the bond although the investor receives some stability for their investments in form of less money. This kind of bond protects bondholders from the risk of increasing interest rates.

Protective covenants are designed to protect lenders from issuer actions and a lender has a right to call back the obligations from the borrower. Protective covenants have lower interest rates and are mainly used to lower the risk of bonds. AAA represents a bond with very strong qualities and any investor would prefer investing in suck kind of a bond.

Interest payment on a floater may be lower compared to the rate paid on fixed rate bonds. At times, floaters tied to T-bills may further fall especially during political crisis. The coupon rates on floaters tends to reduce with short term benchmarks and have both high credit risk and sector risks because they are mostly issued by financial institutions.

Question 4

A three year 8% bonds will provide highest possible profits in case of any decrease in market interest rates since the maturity period is very low and is not subject to many risks such as interest risks. The other investments are related to longer periods (10 years) which may be subject to many risks such as inflation and interest rate risks.

Question 5

Companies would rate their bonds to attract more investors especially when their bonds offer better in an industry in terms of interest rates and other factors which may give a company good reputation.

A bond with AAA rating from DBRS would indicate that the bond has very low interest risks because AAA takes into consideration all the financial strengths of a particular company. AAA indicates superiority in financial strengths as well as stability in an organization’s economic environment after taking care of all the interest risks.

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Kymriah to Treat B-Cell Cancer

Kymriah to Treat B-Cell Cancer

BiologyStudents Name

Institution of Affiliation

Date

Kymriah to Treat B-Cell Cancer

Kymriah is a chimeric antigen receptor (CAR) T-cell therapy that was developed by Novartis. The drug is able to produce prolonged complete responses with minor side effects in adults with relapsed or those with refractory diffuse large B-cell lymphoma (DLBCL). The drug is also used in the treatment of the B-cell acute lymphoblastic leukemia in the patients who are aged 25 years and below. It is used to treat individuals whose cancer treatment has not gotten better with other therapies or has relapsed for two or more times. Further studies are ongoing to test the efficiency of the drug I the treatment of different types of cancer. Kymriah is a drug that was developed using the patients T-cells, which happens to be one of the immune system cells. According to Gill, a gene for a specific receptor, chimeric antigen receptor, is added to the T-cell in the laboratory and the changed T-cell now the CAR T-cells are cultured in large numbers in the laboratory, and they are provided to the patients by infusion. The drug, Kymriah binds to the protein CD 19, that is found in some Lymphoma and Leukemia patient cells, aiding the body’s immune system in destroying the cancer cell.

Kymriah was the first cell-based gene therapy to obtain validation by the United States Food and Drug Administration (FDA). In accordance with Gardner views, the CAR-T drug was meant for the treatment of relapsing or refractory acute lymphoblastic leukemia and non-Hodgkin’s lymphoma among the pediatric and young adult patient of 25 years and below. Acute lymphoblastic leukemia is the most frequent type of leukemia in children. Acute lymphoblastic leukemia is marked by the bone marrow producing too many white blood cells, the lymphocytes to which fail to develop correctly. The excess development of the abnormal white blood cells causes swellings and damage to the internal organs preventing the body from producing other blood cells. The prevention of the formation of different blood cells especially the red blood cells that are responsible for the transport of oxygen around the body tissues, result to anemia and as well dampened immune response. It is in a similar manner that the diffuse large B-cell lymphoma, which is the most common form of non-Hodgkin’s lymphoma is an aggressive cancer of the lymphatic system that is caused by the accumulation of the abnormal B-cells.

The new analysis of the trial data on the Novartis Kymriah CAR-T therapy that were presented at the 59th American Society of Hematology annual meeting indicates that the drug sustained complete responses at six months in adults with a difficult to treat the form of leukemia cancer. The CAR-T therapy offers a new treatment approach in the sense that it is specially produced for the treatment of an individual patient. During the process of treatment, the T-cells are drawn from the blood of the patient and then reprogrammed in the laboratory to develop the T-cells to which are genetically programmed to hunt and kill the patient’s cancer cells.

According to the data obtained from the Juliet’s trail that was led by the researchers from the University of Pennsylvania indicate an overall response rate (ORR) of 53% in the patients taking the Kymriah medication, with 40% achieving a complete response (CR) and 14% achieving a partial response (PR) (Wohlfarth). At six months, 30 percent of the patients were in complete response, with a 74 percent relapse-free rate onset of response, while the median duration of response was not reached. According to the principal investigator, Stephen J. Schuster, at the time of the trial enrollment, the patients with the DLBCL had been through multiple rounds of chemotherapy, and a significant number had unsuccessful stem cell transplants, and this left the patients with few options and poor prognosis. With the availability of the Kymriah drug, the team was able to significantly increase the chances of achieving and maintaining a sustained response without the stem cell transplant, and this was a demonstration of the benefit caused by the Kymriah drug in the treatment of the lethal blood cancer.

Concerning safety, the cytokine release syndrome (CRS) that can result when engineered cells get activated into the body of the patient, occurred in 58 percent of all the treated patients with the Kymriah drug, with 23 percent of them experiencing three-quarters cytokine release syndrome. 21 percent of the patients experienced any grade neurologic events, and 12 percent of the patients possessed three-quarters neurologic adverse events that were managed by supportive care. Grade three-quarters cytopenias lasting more than 28 days, grade three-quarters infection and grade three-quarters febrile neutropenia occurred in 27 percent, 20 percent and 13 percent of the patients respectively. According to Samit Hirawat, while the immediate response to the treatment by the drug is a marker for efficacy, the physicians and patients require treatment options that provide sustained reactions over time with as consistency in the safety profile.

Additional analysis of the data obtained from the ELIANA clinical trial indicates impressive results in the 75 patients that were treated with the Kymriah drug (Thomas et al.). The investigation found the overall remissions rate within three months was 81 percent, the rates of the event-free survival were 73 percent at six months and 50 percent at 12 months. The overall survival rate was 90 percent and 76 percent over the same time intervals. The follow-up analysis of the results that were obtained from the ZUMA-1 trial that investigated the effectiveness of axicabtagene ciloleucel in the patients with the refractory non-Hodgkin’s lymphoma also indicated impressive outcomes. According to the analysis, more than one year after the treatment, 42 percent of the 108 patients enrolled in the ZUMA-1 trial had maintained remission while 40 percent of the patients exhibited no evidence that pointed them to have cancer. Besides more than half of the patients were alive at the median follow up of 15.4 months, and that is more than double the median survival for 6.6 months for the patients treated with the conventional therapy aside from the Kymriah therapy. Therefore the efficacy of the Kymriah drug can be said to be high, and that’s why the Food and Drug Administration opted to license the drug for commercial use.

The Kymriah drug just like other drugs has it is own mechanism of action. The primary purpose of the CAR-T therapy is to eliminate the CD-19 expressing malignant and normal cells with specificity and increased chances of remission. According to Anton, the Tisagelecleucel also known as CTL019 is a CD19 that is directly genetically modified immunotherapy that is genetically targeted to the treatment of specific patients. CTL019 is an adoptive immunocellular cancer therapy that is programmed to use the autologous peripheral blood T- cells that have been coded with a transgene encoding in chimeric antigen receptor (CAR) to identify and eliminate the CD19 cells that express that malignant and non-malignant cells. The CAR is comprised of a murine single-chain antibody fragment that recognizes the CD19 cells and is fused to the intracellular signaling domains from the 4-1BB (CD137) and CD3-zeta. The CD3-zeta component is significant for the initiation of the T-cell activation and anti-tumor activity while the 4-1BB enhances the expansion and most fundamentally the persistence of the tisagenlecleucel. Upon the binding to the CD19 expressing cells, the CAR transmits a signal to promote the T- cell expansion, activation, target cell elimination as well as the persistence of the tisagenlecleucel. The transduced T-cells expand in vivo to engage and as well eliminate the CD19 expressing cells and may inhibit immunological endurance to assist in supporting a long-lasting remission.

Concerning dosage, the treatment course consists of the fludarabine and cyclophosphamide lympho-depleting chemotherapy that is followed by the infusion of Kymriah drug. According to the directions provided by Bachmeier, Kymriah is provided as a single dose unit that contains the chimeric antigen receptor (CAR) viable positive T- cells. The dosage is based on the patient’s weight that is reported at the time of leukapheresis that includes: For the patients below 50kgs, the dosage is 0.2 to 5.0 x 106 CAR-positive T-cell per kg body weight while for the patients above 50kgs the standard dosage is 0.1 to 2.5 x 108 CAR-positive viable T cells. For the Lympho-depleting chemotherapy: Fludarabine (30 mg/m² intravenous daily for four days) and cyclophosphamide (500 mg/m² intravenous daily for two days starting with the first dose of fludarabine). Infuse Kymriah drug for 2 to 14 days after completion of the lympho-depleting chemotherapy.

Despite the effectiveness of the Kymriah drug, there are lots of side effects are said to accompany its administration such as cytokine release syndrome, hypogammaglobulinemia, fever, decreased appetite and infections of unspecified pathogens. A headache, bleeding episodes, low blood oxygen, vomiting fatigue, delirium, and acute kidney injuries are just among the side effects of the administration of the Kymriah drug in accordance with Jones.

The advancement in the field of medicine has enabled and as well led to the development of drugs that are capable of curing diseases that for a long time disturbed and threatened the extinction of the human race. The Kymriah drug, as a chemotherapy for cancer treatment, is one of the many such drugs that have restored hope to the people especially the patients of cancer. Kymriah is a drug that was manufactured by the Novartis Company, directed to the detection and elimination of the CD19 cells. The clinical trials have proved the efficacy of the drug with over 80 percent success, and this led to its approval by the Food and Drugs Administration proving it safe for commercialization. The Kymriah as well can increase the risk of life-threatening infections that may lead to death and therefore it is advisable to seek medical attention upon the development of symptoms such as fever, chills or bleeding just after the drug use.

Work Cited

Gill, Saar, and Carl H. June. “Going viral: chimeric antigen receptor T‐cell therapy for hematological malignancies.” Immunological reviews 263.1 (2015): 68-89.

Gardner, Rebecca A., et al. “Intent to treat leukemia remission by CD19CAR T cells of defined formulation and dose in children and young adults.” Blood (2017): blood-2017.

Wohlfarth, Philipp, Nina Worel, and Georg Hopfinger. “Chimeric antigen receptor Tcell therapy—a hematological success story.” memo-Magazine of European Medical Oncology (2018): 1-6.

Hirawat, Samit, and Langdon Miller. “Methods for dosing an orally active 1, 2, 4-oxadiazole for nonsense mutation suppression therapy.” U.S. Patent No. 9,877,952. 30 Jan. 2018.

Thomas, Xavier, and Etienne Paubelle. “Tisagenlecleucel-T for the treatment of acute lymphocytic leukemia.” Expert opinion on biological therapy just-accepted (2018).

Anton, Roman. “Advances in Cancer Immunology and Immunotherapy.” Global Journal of Medical Research (2018).

Bachmeier, Christina. “Tisagenlecleucel Kymriah Novartis Pharmaceuticals Corp.—all entries with PAPs.”

JONES, DOW. “Novartis: receives first ever FDA approval for a CAR-T cell therapy, Kymriah (TM)(CTL019), for children and young adults with B-cell ALL that is refractory or has relapsed at least twice.”

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The biological perspective of depression argues that depression is as a result of an imbalance of the brain chemicals, the ne

The biological perspective of depression argues that depression is as a result of an imbalance of the brain chemicals, the ne

Biology

Students Name

Institution of Affiliation

Date

The biological perspective of depression argues that depression is as a result of an imbalance of the brain chemicals, the neurotransmitters. Various compounds are used by the brain as messengers to communicate with other parts of the brain as well as the nervous system. The neurons communicate through the chemical messengers, and they are in constant communication through the exchange of the neurotransmitters. The neurons communication is essential to the brain as it aids the brain to carry out its functions. The imbalance of neurotransmitters can be articulated to the development of depression. The monoamine hypothesis has the suggestion that the lowered levels of the brain chemicals such as serotonin, dopamine, and norepinephrine to which result in the symptoms of depression.

The imbalance of serotonin levels is said to influence a person’s mood and eventually lead to depression. There are possible problems that are associated with the imbalance of the serotonin levels, and this includes reduced brain cell production of serotonin, the inability of the serotonin to reach the receptors and as well can be attributed to the shortage of the chemical trypan from which serotonin is made. In case any of the above biochemical problems do occur, it is believed that one has a high probability of being depressed.

Depression can also be related to abnormalities in the circadian rhythm. Such examples include the rapid eye movement sleep, a stage in which dreaming do occur, may be intense and quick to arrive in people with depression. Rapid eye movement sleep relies on decreased serotonin levels in the brain stem. The serotonin levels are impaired by the compounds such as the antidepressants, to which increase the level of serotonin levels in the brain stem structures. The serotonergic system tends to be least active during sleep and most active during wakefulness. Continued wakefulness due to the deprivation of sleep tend to activate the serotonergic neurons, and this leads to the same effect that is caused by the therapeutic effect of anti-depressants like the selective serotonin reuptake inhibitors (SSRIs). The depressed people exhibit a significant elevation in the moods after deprivation of sleep The selective serotonin reuptake inhibitors may directly depend on the rise of the central serotonergic neurotransmission for their therapeutic effect, the same effect to which alter the cycles of being awake and that of sleep.

According to research, the effects of light therapy on the seasonal affective disorder suggest that light deprivation is related to the lowered activity in the serotonergic system as well as to the abnormalities in the sleep cycle that include insomnia. The exposure to light as well targets the serotonergic system and therefore provide more support for the essential role to which the serotonergic system play to the development of depression. Light therapy and sleep deprivation target the same brain neurotransmitter system and brain sites the same way the antidepressant drugs and therefore, they are also used in the treatment of depression.

The increase as well as the decrease in sleep length also play a significant role and can be a significant risk factor for the development of depression. The patients who are diagnosed with major depressive disorders sometimes may manifest diurnal and seasonal variations of symptoms severity, even during the no-seasonal depression. The daily mood improvement is associated with the activity of the dorsal neural networks, and as well a rise in the mean core temperature is observed. A proposition made by one of the hypothesis indicates that depression is as a result of a phase shift. The exposure to daylight leads to decreased serotonin levels due to reduced transport activity, and this may underlie the seasonal development of depression in individuals. In short, the biological perspective of depression is of the opinion that depression is due to a reduction or alteration of the serotonin levels which result in mood swings to which lead to the development of depression resulting from the abnormalities in the circadian rhythm.

Reference

Demirkan, A., Penninx, B., Hek, K., Wray, N., Amin, N., Aulchenko, Y., Middeldorp, C. (2011). Genetic risk profiles for depression and anxiety in adult and elderly cohorts. Molecular Psychiatry, 16(7), 773–783.

Silberg, J., Maes, H., & Eaves, L. (2010). Genetic and environmental influences on the transmission of parental depression to children’s depression and conduct disturbance: An extended children of twins study. Journal of Child Psychology and Psychiatry, 51(6), 734–744.

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Larger Mammalian Body Size Leads to Lower Retroviral Activity

Larger Mammalian Body Size Leads to Lower Retroviral Activity

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Larger Mammalian Body Size Leads to Lower Retroviral Activity

The retroviruses have affected mammals affected mammals for more than 100 years, leaving the descendants of the hosts in the host genomes to which are referred to as the endogenous retrovirus. The amount of the endogenous retrovirus is to some extent determined by the retrovirus’ mode of replication, but also a suggestion that the host’s life history traits have the possibilities of suppressing or enhancing the retrovirus activity. According to the research results, body size limits the ability of the endogenous retrovirus to replicate due to their adverse effects impacted on the host.

The endogenous retrovirus is favored by lower body size and higher horizontal transmission rates because the retroviral integration is tumorigenic and the negative correlation between body size and the endogenous retrovirus arise from the need to reduce the risk of cancer having the assumptions that the risk scales positively with the body size. It is however contrasted by the research model that indicates that the lifetime risk of cancer tend to be relatively invariant among the mammals regardless of their body size best regarded as the Peto’s Paradox, to which indicates that the larger bodies mammals have as well evolved the mechanisms of limiting the endogenous retrovirus activity.

The fixation of a new endogenous retrovirus insertion is influenced by the fitness consequences of the host. A smaller number of the endogenous retrovirus have been exapted and possess beneficial actions to the host, although the integration of the retrovirus into the host’s genes have a highly deleterious impact, as the consequent alteration of the gene expression has the possibilities of leading to malignant transformations. Also, the illegitimate recombination between the endogenous retrovirus at different loci may also have the deleterious effect, and therefore the uncontrolled proliferation of the endogenous retrovirus would be extremely detrimental to the host. The process of reproduction could only be limited either through cessation replication or by the host-mediated suppression. The vertebrates’ genomes have evolved a variety of responses that tend to act at various stages of their viral life cycle to limit the retroviral replication along with the associated tumorigenic potential.

The mice and the humans are the two mammalian species are among the first to get their genomes sequenced, indicating variations in the in the patterns of the endogenous retrovirus activity. The human endogenous retroviruses are inactive, with a noticeable deceleration in activity over the last 25 million years which is in contrast to that of the mice genome showing no signs of deceleration in the endogenous retrovirus activity having active and unfixed numbers. The number of mates, as well as the type of placenta, have the possibility of influencing the abundance of the endogenous retrovirus through an increased risk of the horizontal or the vertical retroviral transmission. A possible cofounder includes the effective population size of the host; the species with a higher effective population size are expected to be more efficient at purging slightly deleterious mutations such as those incurred by the endogenous retrovirus proliferation. Being a researcher, the next experiment that I could do is based on the Human Tripartite Motif 5α Domains.

Reference

Katzourakis, Aris, et al. “Larger mammalian body size leads to lower retroviral activity.” PLoS pathogens 10.7 (2014): e1004214.

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