While much remains to be learned about the role of nucleosomes and chromatin structure and function, recent research indicates that in vivo chemical modification of histones is associated with changes in gene activity. One recent study determined that the acetylation of H3 and H4 is associated with 21.1% and 13.8% increases in yeast gene activity, respectively, and that yeast heterochromatin is hypomethylated relative to the genome average. Discuss the significance of these findings in terms of nucleosomes-DNA interactions and, gene activity. BE SPECIFIC IN YOUR ANSWER