what is the current state of genomic sequencing and what are the future technologies that will be used in clinical settings to further personalized medicine?

Diagnostics:
1. Epigenetics (<3 pages) - vikram subtopics: description, current state of research, future directions and applications a. i will discuss the applications epigenetics as well propose a future direction for use in a diagnostic manner. advances understanding completion human genome project has led to an abundance personalized data. the this science advances informatics allows new opportunities integrate new technologies with diagnostics and therapeutics. b. molecular basis epigenetics, specifically chromatin immunoprecipitation. a. dna methylation chromatin remodeling b. structural inheritance systems c. how can play role angelman syndrome and prader-willi syndrome c. present bioinformatics methods are playing increasing role computational epigenetics d. some chromosomal abnormalities is associated it. a. inversions (both de novo familial) 1.advancing clinical utility genomics technology (<3 background information, informatics, directions i sequencing discussing the current shortcomings field. addition of this touching base on products like genechip other dna microarray devices they be implemented evolving informatics field. a. obtaining data gotten faster less expensive, but bottlenecks exist not just regulatory process also correlating sequence outcomes. a key driver is advancement genes advances in pipelines management. major players sequencing technologies already offering analysis storage cloud services addition to just instrumentation. that break bottleneck and drive additional crucial advancing translation of sequencing clinic b. especially genechip c. benefits prenatal setting. a.a. verinata’s non-invasive method determine chromosomal abnormalities limitations: 1. cost (0.5 description cost, insurance coverage, legislation i costs availability associated human whole-genome sequencing. provide details research funding, and payment sequencing, any legislation related to whole-genome general public. a. advantages>