MD BIOL 102 – Meiosis The Importance of Cell Cycle
Subject: Biology    / General Biology
Question
Meiosis
Experiment 2: The Importance of Cell Cycle Control
Some environmental factors can cause genetic mutations which result in a lack of proper cell cycle control
(mitosis). When this happens, the possibility for uncontrolled cell growth occurs. In some instances, uncontrolled growth can lead to tumors, which are often associated with cancer, or other biological diseases. In this experiment, you will review some of the karyotypic differences which can be observed when comparing normal, controlled cell growth and abnormal, uncontrolled cell growth. A karyotype is an image of the
complete set of diploid chromosomes in a single cell. Materials
*Computer Access
*Internet Access *You Must Provide Procedure:
1. Begin by constructing a hypothesis to explain what differences you might observe when comparing the
karyotypes of human cells which experience normal cell cycle control versus cancerous cells (which
experience abnormal, or a lack of, cell cycle control). Record your hypothesis in Post-Lab Question 1.
Note: Be sure to include what you expect to observe, and why you think you will observe these features. Think about what you know about cancerous cell growth to help construct this information
2. Go online to find some images of abnormal karyotypes, and normal karyotypes. The best results will
come from search terms such as “abnormal karyotype”, “HeLa cells”, “normal karyotype”, “abnormal
chromosomes”, etc. Be sure to use dependable resources which have been peer-reviewed
3. Identify at least five abnormalities in the abnormal images. Then, list and draw each image in the Data
section at the end of this experiment. Do these abnormalities agree with your original hypothesis?
Hint: It may be helpful to count the number of chromosomes, count the number of pairs, compare
the sizes of homologous chromosomes, look for any missing or additional genetic markers/flags,
etc. 98 Meiosis
Data
1. 2. 3. 4. 5. 99

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