How can I predict the effect on absorption for a…
How can I predict the effect on absorption for a lipophilic compound if formulated in a solution of cetomacrogol 1000 where the surfactant had a concentration of 0. 4% or a concentration of 0.00004%. Additional Requirements Other Requirements: My thoughts so far ... Lipophilic compounds are generally insoluble in water. Cetomacrogol will reduce the interfacial tension between oil and water, assisting the aborption of a lipophilic compound. 0.4% is above the CMC for cetomacrogol, thus micelles will form. The lipophilic compound will become emulsified in the micelles. 0.00004% is below CMC, at this concentration no micelles will form. If the compound is in a micelle is absorption better because the micelle carries it into the oil layer?