Question 1
1.
Cytopathic and non-cytopathic viruses elicit very different immune responses. The primary
determining factor in the type of immune response to a viral infection is which of the following
(select one)?
Answer
A Initial inflammatory response to virus.
.
B. Whether virus is first recognized by macrophages

or dendritic cells

C. Genome
D
.

type (RNA or DNA) of virus
Whether IgG or IgM antobodies are produced.
1 points

Question 2
1.
Many viruses evade the actions of NK cells by producing viral homologue of the host [x]
receptor.
Answer
1 points

Question 3
1.
This phenomena occurs when memory T-cells specific for one virus are activated during infection by unrelated
virus.
Answer
A Systemic Inflammatory
.
B. Superantigens
C. Antigen

Response Syndrome

Presentation

D Transcytosis
.
E. Heterologous

T-cell Immunity
1 points

Question 4
1.
Match the following immune system cell types with their role in fighting a viral infection
Answer
Answer
Macrophages
ReadA Take up viral antigens in peripheral
Answer
Items. forissues present them to T-cells in
t
Question 4
the lymphoid organs
Dendritic
B. Cells that contain antigen specific
Cells
cell
Read Answer surface receptors and produce
s
Items for oluble antibodies specific for viral
Question ntigens
a4

C. Recognize and kill cells infected by
Helper T
cells viruses through recognition of
Read Answer
specific viral antigens on surface of
Items for
c4
Question ell
D Coordinate adaptive immune
Cytotoxic T.
Cells response by releasing cytokines,
activation macrophages and
Read Answer
Items for timulating B-cells to produce
s
Question 4
antibody.
Natural
E. Scavenger phagocytic cells that are
Killer Cells
am
Read Answerajor source of inflammatory
c
Items for ytokines in innate immunity and
Question lso involved in antigen
a4
Plasmaresentation.
pB
Cells Kill virus infected cells by
F.
Read Answer
r
Items forecognizing the absence of MHC
on
Question 4 surface of infected cells.
3 points

Question 5
1.
Simple Overview of Immune response concept map

Answer
Answer
A Helper T-cell
.
B. Cytotoxic T-cell
C. Macrophage
D Natural Killer Cell
.
E. Dendritic Cell
F.
G
.
H
.

Plasma B-Cell
Naive B-Cell
Naive T-cell

4 points

Question 6
1.
Viruses are intracellular pathogens that can hide within a cell. The adaptive immune response responds to pathogens
using antibodies and T-cells, neither which are capable of entering cells and directly recognizing the virus. Briefy,
describe how the adaptive immune response is able to recognize a cell is infected and eliminate infected cells (Max
5-6 sentences)
Answer

Press Tab to enter the content editor. For the toolbar, press ALT+F10 (PC) or ALT+FN+F10 (Mac).

Path: p
Words:0
2 points

Question 7
1.
Which of the following are mechanims by which antibodies can inhibit a viral infection in
humans (Select all that apply)?
Answer
A Bind
.
B. Bind

to viral polymerase and inhibit its ability to replicate viral genome

to virus antigen and recruit non-specific cells such as macrophages or NK cells to
engulf the virion or kill an infected cell.

C. Recognition of alpha(1,3) galactose which inhibits fusion of enveloped viruses in higher primates
D Bind
.
E. Bind

to viral capsid or viral receptor and sterically prevent binding to host cell receptor
to T-cells and stimulate reelease of cytokines
2 points

Question 8
1.
The two picture below depict the pathways for antigen presentation to T-cells. Match the picture
with the the appropriate presentation pathway/T-cell type.

Answer

T-Cell A
Read Answer Items for
Question 8

T-Cell B
Read Answer Items for
Question 8

Answer
A MHC
.

Class II Presentation to CD4+ T-Cell
(Helper T-Cell)
B. MHC Class I Presentation CD8+ T-Cell
(Cytotoxic T-Cell)
1 points

Question 9
1.

Which of the following mechanisms would enable a virus to evade the immune response (select
all that apply)?
Answer
A Virus downregulates expression of NK cell activating
.
B. Enhance production of perforins by CD8+ T-cells

ligands

C. Activation

of NFkB transcription factor
Inhibit expression of MHC Class I molecules on surface of cell.

D
.
E. Inhibition

of cellular proteasome pathways
2 points

Question 10
1.
A recent paper suggests that a mechanism by which the influenza virus can evade the adaptive
immune response is to kill influenza specific B-cells in the respiratory tract. Explain why this
might aid an influenza infection. In addition, given what you have learned about viruses and the
immune response, suggest a mechanism the virus could use to specifically kill B-cells (5-6
sentences max)..
Answer

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Words:0
2 points

Question 11
1.
The figure below depicts antigen presentation to T-cells of two different strains of Dengue virus.
Explain why the difference in the viral antigen sequences alters the immune response to the
virus. How might viruses take advantage of this to evade the immune response (3-4 sentences
max)?

Answer

Press Tab to enter the content editor. For the toolbar, press ALT+F10 (PC) or ALT+FN+F10 (Mac).

Path: p
Words:0
2 points
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