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Question 1 1. Cytopathic and non-cytopathic viruses elicit very different immune responses. The primary determining factor in the type of immune response to a viral infection is which of the following (select one)? Answer A Initial inflammatory response to virus. . B. Whether virus is first recognized by macrophages or dendritic cells C. Genome D . type (RNA or DNA) of virus Whether IgG or IgM antobodies are produced. 1 points Question 2 1. Many viruses evade the actions of NK cells by producing viral homologue of the host [x] receptor. Answer 1 points Question 3 1. This phenomena occurs when memory T-cells specific for one virus are activated during infection by unrelated virus. Answer A Systemic Inflammatory . B. Superantigens C. Antigen Response Syndrome Presentation D Transcytosis . E. Heterologous T-cell Immunity 1 points Question 4 1. Match the following immune system cell types with their role in fighting a viral infection Answer Answer Macrophages ReadA Take up viral antigens in peripheral Answer Items. forissues present them to T-cells in t Question 4 the lymphoid organs Dendritic B. Cells that contain antigen specific Cells cell Read Answer surface receptors and produce s Items for oluble antibodies specific for viral Question ntigens a4 C. Recognize and kill cells infected by Helper T cells viruses through recognition of Read Answer specific viral antigens on surface of Items for c4 Question ell D Coordinate adaptive immune Cytotoxic T. Cells response by releasing cytokines, activation macrophages and Read Answer Items for timulating B-cells to produce s Question 4 antibody. Natural E. Scavenger phagocytic cells that are Killer Cells am Read Answerajor source of inflammatory c Items for ytokines in innate immunity and Question lso involved in antigen a4 Plasmaresentation. pB Cells Kill virus infected cells by F. Read Answer r Items forecognizing the absence of MHC on Question 4 surface of infected cells. 3 points Question 5 1. Simple Overview of Immune response concept map Answer Answer A Helper T-cell . B. Cytotoxic T-cell C. Macrophage D Natural Killer Cell . E. Dendritic Cell F. G . H . Plasma B-Cell Naive B-Cell Naive T-cell 4 points Question 6 1. Viruses are intracellular pathogens that can hide within a cell. The adaptive immune response responds to pathogens using antibodies and T-cells, neither which are capable of entering cells and directly recognizing the virus. Briefy, describe how the adaptive immune response is able to recognize a cell is infected and eliminate infected cells (Max 5-6 sentences) Answer Press Tab to enter the content editor. For the toolbar, press ALT+F10 (PC) or ALT+FN+F10 (Mac). Path: p Words:0 2 points Question 7 1. Which of the following are mechanims by which antibodies can inhibit a viral infection in humans (Select all that apply)? Answer A Bind . B. Bind to viral polymerase and inhibit its ability to replicate viral genome to virus antigen and recruit non-specific cells such as macrophages or NK cells to engulf the virion or kill an infected cell. C. Recognition of alpha(1,3) galactose which inhibits fusion of enveloped viruses in higher primates D Bind . E. Bind to viral capsid or viral receptor and sterically prevent binding to host cell receptor to T-cells and stimulate reelease of cytokines 2 points Question 8 1. The two picture below depict the pathways for antigen presentation to T-cells. Match the picture with the the appropriate presentation pathway/T-cell type. Answer T-Cell A Read Answer Items for Question 8 T-Cell B Read Answer Items for Question 8 Answer A MHC . Class II Presentation to CD4+ T-Cell (Helper T-Cell) B. MHC Class I Presentation CD8+ T-Cell (Cytotoxic T-Cell) 1 points Question 9 1. Which of the following mechanisms would enable a virus to evade the immune response (select all that apply)? Answer A Virus downregulates expression of NK cell activating . B. Enhance production of perforins by CD8+ T-cells ligands C. Activation of NFkB transcription factor Inhibit expression of MHC Class I molecules on surface of cell. D . E. Inhibition of cellular proteasome pathways 2 points Question 10 1. A recent paper suggests that a mechanism by which the influenza virus can evade the adaptive immune response is to kill influenza specific B-cells in the respiratory tract. Explain why this might aid an influenza infection. In addition, given what you have learned about viruses and the immune response, suggest a mechanism the virus could use to specifically kill B-cells (5-6 sentences max).. Answer Press Tab to enter the content editor. For the toolbar, press ALT+F10 (PC) or ALT+FN+F10 (Mac). Path: p Words:0 2 points Question 11 1. The figure below depicts antigen presentation to T-cells of two different strains of Dengue virus. Explain why the difference in the viral antigen sequences alters the immune response to the virus. How might viruses take advantage of this to evade the immune response (3-4 sentences max)? Answer Press Tab to enter the content editor. For the toolbar, press ALT+F10 (PC) or ALT+FN+F10 (Mac). Path: p Words:0 2 points Save and Submit Click Save and Submit to save and submit. Click Save All Answers to save all answers.