what is the current state of genomic sequencing and what are the future technologies that will be used in clinical settings to further personalized medicine?Diagnostics:
1. Epigenetics (<3 pages) - vikram subtopics: description, current state of research, future directions and applications a. i will discuss the applications epigenetics as well propose a direction for use in diagnostic manner. advances understanding completion human genome project has led to an abundance personalized data. this science informatics allows new opportunities integrate technologies with diagnostics therapeutics. b. discuss molecular basis epigenetics, specifically chromatin immunoprecipitation. a. dna methylation remodeling b. structural inheritance systems c. discuss how can play role angelman syndrome prader-willi syndrome c. present bioinformatics methods are playing increasing computational epigenetics d. discuss some chromosomal abnormalities is associated it. a. inversions (both de novo familial) 1.advancing clinical utility genomics technology (<3 background information, informatics, directions i dna sequencing discussing shortcomings field. addition i touching base on products like genechip other microarray devices they be implemented evolving field. a. obtaining data gotten faster less expensive, but bottlenecks exist not just regulatory process also correlating sequence outcomes. key driver advancement genes pipelines management. major players already offering analysis storage cloud services instrumentation. that break bottleneck drive additional crucial advancing translation clinic b. discuss especially genechip c. discuss benefits prenatal setting. a. verinata’s non-invasive method determine abnormalities limitations: 1. cost (0.5 vikram subtopics: description cost, insurance coverage, legislation i costs availability whole-genome sequencing. provide details research funding, payment sequencing, any legislation related general public. a. i advantages>