Subject: Biology    / General Biology
Question

Question 1
1.
Antibodies directed against HIV can enhance the infection by facilitating entry of virus into immune cells.
Answer
True
False
2 points
Question 2
1. The most common mode of transmission of HIV worldwide is which of the following (select one)?
Answer

A. Sharing of intravenous needles

B. Heterosexual contact

C. Blood Transfusion

D. Homosexual contact
2 points
Question 3
1.
Match the role in HIV infection in the concept map below of the following HIV proteins

Answer

Box A
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Box B
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Box C
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Box D
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Box E
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Box F
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Box G
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Box H
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Box I
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Answer
1. Integrase
2. Rev
3. Nef
4. GP120
5. Tat
6. Vpu
7. Vpr
8. Reverse Transcriptase
9. Vif

5 points
Question 4
1.
Match the following phases of a HIV infection with their associated symptoms or clinical parameters.
Answer

Helper T-cell levels below 200/ml
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Steady Decline in Helper T-cell levels
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Elevated levels of Cytoxic T-cells
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Flu-Like Symptoms
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Initial infection of memory T-cells
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Highest level of viremia
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Answer
A. Symptomatic Phase/AIDS
B. Acute Phase
C. Asymptomatic Phase

3 points
Question 5
1.
It is estimated that the genetic diversity of HIV in a single individual exceeds that of the worldwide diversity of Influenza A during a typical pandemic.
Answer
True
False
2 points
Question 6
1.
Individuals infected with HIV are much more likely to develop aggressive cancers such as Kaposi’s sarcoma and B-cell lymphoma. Explain why this is the case (4-5 sentences max).
Answer
Press Tab to enter the content editor. For the toolbar, press ALT+F10 (PC) or ALT+FN+F10 (Mac).
In case of HIV, the immune system of the individual is compromised. The HIV infected person is susceptible to many infections because the Helper
T cell count becomes low. The B cells which produce antibodies are also affected. In case of Kaposi sarcoma, there is a co-infection with its
oncogenic virus.

Path: p
Words:0

2 points
Question 7
1.
Visit the World Health Organization (WHO) website on HIV/AIDs (.who.int/hiv/en/”>www.who.int/hiv/en/) and study the statistics on world wide infections. Fill in the blanks below for the statistic for HIV infection as of the end of 2011.
Blank 1 million individuals worldwide have died of AIDs since its discovery in the early 1980s.
Blank 2 million individuals die in 2011 from AIDs
Blank 3 million individuals worldwide are infected by HIV.
Blank 4 million individuals were newly infected with HIV in 2011.
Answer
2 points
Question 8
1.
One of the features of HIV that has made it such a severe global health issue is the fact that it possess an asymptomatic phase that can last many years. Explain in 5-6 sentences why HIV has a long asymptomatic phase and how this has contributed to the severity and spread of the AIDs pandemic.
Answer
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