The accuracy of DNA polymerase activity is subject to a 3? exonucleolytic
Subject: Biology / Biochemistry
Question
The accuracy of DNA polymerase activity is subject to a 3? exonucleolytic proofreading step. Which of the following statements is true?
.364px;="" collapse;="" 12px="">
The polymerase and exonuclease site are physically close to each other.
The 3? exonuclease has very high specificity for mismatched pairs.
The K M for DNA polymerase for chain extension from a mismatch is about 3 orders of magnitude higher, allowing the mismatch to reach the exonuclease site.
All of the listed statements are true.
